Dwivedi Shiwangi, Kushalan Sharanya, Paithankar Jagdish Gopal, D'Souza Leonard Clinton, Hegde Smitha, Sharma Anurag
Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Division of Environmental Health and Toxicology, Deralakatte, Mangaluru, India.
Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Division of Bioresource and Biotechnology, Deralakatte, Mangaluru, India.
J Pharm Pharmacol. 2022 Apr 20;74(4):516-536. doi: 10.1093/jpp/rgab044.
Oxidative stress is the most common factor mediating environmental chemical-induced health adversities. Recently, an exponential rise in the use of phytochemicals as an alternative therapeutics against oxidative stress-mediated diseases has been documented. Due to their free radical quenching property, plant-derived natural products have gained substantial attention as a therapeutic agent in environmental toxicology. The present review aimed to describe the therapeutic role of phytochemicals in mitigating environmental toxicant-mediated sub-cellular and organ toxicities via controlling cellular antioxidant response.
The present review has covered the recently related studies, mainly focussing on the free radical scavenging role of phytochemicals in environmental toxicology.
In vitro and in vivo studies have reported that supplementation of antioxidant-rich compounds can ameliorate the toxicant-induced oxidative stress, thereby improving the health conditions. Improving the cellular antioxidant pool has been considered as a mode of action of phytochemicals. However, the other cellular targets of phytochemicals remain uncertain.
Knowing the therapeutic value of phytochemicals to mitigate the chemical-induced toxicity is an initial stage; mechanistic understanding needs to decipher for development as therapeutics. Moreover, examining the efficacy of phytochemicals against mixer toxicity and identifying the bioactive molecule are major challenges in the field.
氧化应激是介导环境化学物质所致健康不良影响的最常见因素。最近，有文献记载，作为对抗氧化应激介导疾病的替代疗法，植物化学物质的使用呈指数级增长。由于其自由基淬灭特性，植物源天然产物作为一种治疗剂在环境毒理学中受到了广泛关注。本综述旨在描述植物化学物质通过控制细胞抗氧化反应在减轻环境毒物介导的亚细胞和器官毒性方面的治疗作用。
本综述涵盖了最近的相关研究，主要关注植物化学物质在环境毒理学中的自由基清除作用。
体外和体内研究报告称，补充富含抗氧化剂的化合物可以改善毒物诱导的氧化应激，从而改善健康状况。改善细胞抗氧化池被认为是植物化学物质的一种作用方式。然而，植物化学物质的其他细胞靶点仍不确定。
了解植物化学物质减轻化学诱导毒性的治疗价值只是一个初始阶段；作为治疗方法开发，需要对其作用机制进行深入研究。此外，研究植物化学物质对混合毒性的疗效以及鉴定生物活性分子是该领域的主要挑战。
