Mor Satbir, Khatri Mohini, Punia Ravinder, Sindhu Suchita
Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar 125001, Haryana, India.
Mini Rev Med Chem. 2022;22(1):115-163. doi: 10.2174/1389557521666210325115218.
The search for new anticancer agents is considered a dynamic field of medicinal chemistry. In recent years, the synthesis of compounds with anticancer potential has increased and a large number of structurally varied compounds displaying potent anticancer activities have been published. Pyrazole is an important biologically active scaffold that possesses nearly all types of biological activities. The aim of this review is to collate literature work reported by researchers to provide an overview on in vivo and in vitro anticancer activities of pyrazole based derivatives among the diverse biological activities displayed by them and also to present recent efforts made on this heterocyclic moiety regarding anticancer activities. This review has been driven by the increasing number of publications on this issue, which have been reported in the literature since the end of the 20 century (from 1995-to date).
寻找新型抗癌药物被认为是药物化学领域一个充满活力的研究方向。近年来，具有抗癌潜力的化合物的合成数量有所增加，大量结构各异且具有强效抗癌活性的化合物已被发表。吡唑是一种重要的生物活性骨架，几乎具备所有类型的生物活性。这篇综述的目的是整理研究人员报告的文献工作，以概述吡唑类衍生物在其展现的多种生物活性中体内和体外的抗癌活性，并介绍在这个杂环部分有关抗癌活性方面所做的最新研究工作。这篇综述是受自20世纪末（从1995年至今）以来文献中关于此问题的出版物数量不断增加所推动。
