Department of Chemistry, School of Advanced Sciences, VIT, Vellore, Tamil Nadu, India/ Rajiv Gandhi Institute of Pharmacy, Trikaripur, Kasaragod, Kerala, India.
Department of Chemistry, School of Advanced Sciences, VIT, Vellore, Tamil Nadu, India.
Pak J Pharm Sci. 2020 Sep;33(5):1971-1979.
Diabetes mellitus is an epidemic that is growing worldwide at an alarming rate. The need for plant-based drugs to combat this epidemic led to the isolation of three new compounds, namely 1-Benzoyloxy-8-tetradecanoyloxy-geranilane (1), 1-Benzoyloxy-8-(octadec-9ꞌꞌ-enoyl) geranilane (2), and 1-Benzoyloxy-8-octadecanoyloxygeranilane (3), from the roots of Premnaherbacea. Their structures were deciphered by H NMR, C NMR, and 2D-NMR. In vitro (α-amylase and α-glucosidase inhibitory activity) and in vivo antidiabetic activity (streptozotocin- nicotinamide model) were conducted using various groups for which various biochemical parameters and histopathology studies were done. This study confirmed that 1-Benzoyloxy-8-(octadec-9ꞌꞌ-enoyl) geranilane from roots of Premna herbacea have significant antidiabetic and antioxidant activity, thus indicating a corrective effect on diabetes and its complications.
糖尿病是一种在全球范围内以惊人速度增长的流行疾病。为了对抗这种疾病，人们需要植物类药物，这导致从 Premna herbacea 的根部分离出三种新化合物，分别为 1-苯甲酰氧基-8-十四烷酰氧基香叶基丙烯酰胺（1）、1-苯甲酰氧基-8-（十八碳-9-烯酰基）香叶基丙烯酰胺（2）和 1-苯甲酰氧基-8-十八烷酰氧基香叶基丙烯酰胺（3）。它们的结构通过 1H NMR、13C NMR 和 2D-NMR 确定。通过不同的组别进行体外（α-淀粉酶和α-葡萄糖苷酶抑制活性）和体内抗糖尿病活性（链脲佐菌素-烟酰胺模型）实验，并对不同组别进行各种生化参数和组织病理学研究。这项研究证实，Premna herbacea 根中的 1-苯甲酰氧基-8-（十八碳-9-烯酰基）香叶基丙烯酰胺具有显著的抗糖尿病和抗氧化活性，因此表明其对糖尿病及其并发症具有纠正作用。
