Panciroli Claudia, Esteve Anna, Muñoz-Ferrer Aida, Abad Jorge, Hernandez Jose Maria, Balaña Carmen, Lucente Giuseppe, Comas Silvia, Villà Salvador
Medical Oncology Department, Catalan Institute of Oncology (ICO), Badalona (Barcelona), Catalonia, Spain.
Sleep Disturbance Unit, Pulmonary Department, Germans Trias i Pujol University Hospital, Badalona (Barcelona), Catalonia, Spain.
Sleep Breath. 2022 Mar;26(1):469-475. doi: 10.1007/s11325-021-02365-5. Epub 2021 Apr 6.
Our aim was to assess if the radiotherapy dose decreased the melatonin levels as well as the quality of life and sleep in brain tumor patients.
We performed a follow-up study on melatonin levels in saliva and its urinary metabolite sulfatoxi-melatonine (STM) samples in patients with brain tumors treated with radiotherapy close to the pineal gland's area. We analyzed the cortisol, cortisone, and excrection of STM normalized by urinary creatinine. In some cases, a polysomnography (PSG) was performed. Quality of life questionnaires, distress scale, and sleepiness inventories were also administered.
We included twelve patients (experimental arm) and eight healthy controls (control group). No differences were observed between experimental arm and control group at baseline. No differences were detected in the experimental arm before and after delivering the radiotherapy. No clinically significant differences were found according to the radiotherapy dose delivered.
Melatonin levels and PSG outcomes do not change after receiving radiotherapy. The findings of this study do not show a statistically significant association between the treatment and the quality of life and sleep.
我们的目的是评估放疗剂量是否会降低脑肿瘤患者的褪黑素水平以及生活质量和睡眠质量。
我们对在松果体区域附近接受放疗的脑肿瘤患者的唾液褪黑素水平及其尿代谢产物硫酸氧基褪黑素（STM）样本进行了随访研究。我们分析了经尿肌酐标准化的皮质醇、可的松和STM排泄情况。在某些情况下，进行了多导睡眠图（PSG）检查。还发放了生活质量问卷、痛苦量表和嗜睡量表。
我们纳入了12名患者（实验组）和8名健康对照者（对照组）。实验组和对照组在基线时未观察到差异。在放疗前后，实验组未检测到差异。根据放疗剂量未发现临床显著差异。
接受放疗后，褪黑素水平和PSG结果没有变化。本研究结果未显示治疗与生活质量和睡眠之间存在统计学上的显著关联。
