Nijakowski Kacper, Surdacki Michał, Sobieszczańska Małgorzata
Department of Conservative Dentistry and Endodontics, Poznan University of Medical Sciences, 60-812 Poznan, Poland.
Student Research Group of Geriatrics and Gerontology, Department of Clinical Geriatrics, Wroclaw Medical University, 50-369 Wroclaw, Poland.
Metabolites. 2022 May 13;12(5):439. doi: 10.3390/metabo12050439.
Melatonin is known as a regulator of circadian sleep and waking rhythm. This hormone secreted by the pineal gland also has protective, oncostatic, and antioxidant properties. This systematic review was designed to answer the question "Is there a relationship between salivary melatonin changes and oncological diseases?". Following the inclusion and exclusion criteria, ten studies were included, according to PRISMA statement guidelines. In all included studies, the diagnostic material was unstimulated whole saliva, in which the melatonin changes were determined by different laboratory methods. Most studies concerned changes in melatonin levels in patients with brain tumours due to a direct effect on the circadian rhythm centres. Other studies focused on disorders of melatonin secretion and its inclusion as a diagnostic marker in patients with prostate cancer and oral squamous cell carcinoma. The association between melatonin changes and sleep quality and chronotype in patients with newly diagnosed lung cancer and lymphoma survivors was also investigated. In conclusion, our systematic review may suggest trends for melatonin secretion alterations in oncological patients. However, due to the significant heterogeneity of the included reports, it is not possible to clearly determine a link between changes in salivary melatonin levels and the oncological diagnosis.
褪黑素被认为是昼夜睡眠和清醒节律的调节因子。这种由松果体分泌的激素还具有保护、抑癌和抗氧化特性。本系统评价旨在回答“唾液褪黑素变化与肿瘤疾病之间是否存在关联？”这一问题。根据PRISMA声明指南，在遵循纳入和排除标准后，纳入了十项研究。在所有纳入的研究中，诊断材料均为非刺激性全唾液，其中褪黑素变化通过不同的实验室方法测定。大多数研究关注脑肿瘤患者褪黑素水平的变化，因为其对昼夜节律中枢有直接影响。其他研究则聚焦于前列腺癌和口腔鳞状细胞癌患者褪黑素分泌紊乱及其作为诊断标志物的纳入情况。还研究了新诊断肺癌患者和淋巴瘤幸存者中褪黑素变化与睡眠质量和昼夜节律类型之间的关联。总之，我们的系统评价可能提示肿瘤患者褪黑素分泌改变的趋势。然而，由于纳入报告的显著异质性，无法明确确定唾液褪黑素水平变化与肿瘤诊断之间的联系。
