红细胞压积对体内血中环孢素测量的影响。
The influence of haematocrit on blood cyclosporin measurements in vivo.
作者信息
Johnston A, Marsden J T, Holt D W
机构信息
Department of Clinical Pharmacology, St Bartholomew's Hospital, London.
出版信息
Br J Clin Pharmacol. 1988 Apr;25(4):509-13. doi: 10.1111/j.1365-2125.1988.tb03336.x.
The influence of haematocrit on blood cyclosporin measurements has been studied in 276 paired blood and plasma samples from 21 renal transplant patients. A highly significant correlation was found between blood and plasma cyclosporin concentrations, r = 0.8744, but the correlation between blood or plasma cyclosporin and haematocrit was not significant. The ratio of blood/plasma cyclosporin did not significantly increase with increasing haematocrit. It was concluded that in vivo the influence of haematocrit on the measurement of blood cyclosporin concentrations was negligible.
对21例肾移植患者的276对血液和血浆样本进行了研究，以探讨血细胞比容对血液中环孢素测量值的影响。血液和血浆中环孢素浓度之间存在高度显著的相关性，r = 0.8744，但血液或血浆中环孢素与血细胞比容之间的相关性不显著。血液/血浆中环孢素的比值不会随着血细胞比容的增加而显著升高。得出的结论是，在体内血细胞比容对血液中环孢素浓度测量的影响可忽略不计。
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