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红细胞压积对体内血中环孢素测量的影响。

The influence of haematocrit on blood cyclosporin measurements in vivo.

作者信息

Johnston A, Marsden J T, Holt D W

机构信息

Department of Clinical Pharmacology, St Bartholomew's Hospital, London.

出版信息

Br J Clin Pharmacol. 1988 Apr;25(4):509-13. doi: 10.1111/j.1365-2125.1988.tb03336.x.

DOI:10.1111/j.1365-2125.1988.tb03336.x
PMID:3382593
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1387814/
Abstract

The influence of haematocrit on blood cyclosporin measurements has been studied in 276 paired blood and plasma samples from 21 renal transplant patients. A highly significant correlation was found between blood and plasma cyclosporin concentrations, r = 0.8744, but the correlation between blood or plasma cyclosporin and haematocrit was not significant. The ratio of blood/plasma cyclosporin did not significantly increase with increasing haematocrit. It was concluded that in vivo the influence of haematocrit on the measurement of blood cyclosporin concentrations was negligible.

摘要

对21例肾移植患者的276对血液和血浆样本进行了研究，以探讨血细胞比容对血液中环孢素测量值的影响。血液和血浆中环孢素浓度之间存在高度显著的相关性，r = 0.8744，但血液或血浆中环孢素与血细胞比容之间的相关性不显著。血液/血浆中环孢素的比值不会随着血细胞比容的增加而显著升高。得出的结论是，在体内血细胞比容对血液中环孢素浓度测量的影响可忽略不计。

相似文献

1
The influence of haematocrit on blood cyclosporin measurements in vivo.红细胞压积对体内血中环孢素测量的影响。
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Effect of hematocrit on cyclosporine (cyclosporin A) in whole blood and plasma of renal-transplant patients.血细胞比容对肾移植患者全血和血浆中环孢素（环孢素A）的影响。
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本文引用的文献

1
In vitro stability of cyclosporin A.环孢素A的体外稳定性
J Clin Pathol. 1983 Jun;36(6):720-1. doi: 10.1136/jcp.36.6.720.
2
Cyclosporin concentrations in whole blood and plasma.全血和血浆中环孢素的浓度。
Clin Chem. 1984 May;30(5):817.
3
Temperature dependency of apparent cyclosporin A concentrations in plasma.
Clin Chem. 1983 Oct;29(10):1865.
4
Effects of sample preparation on concentrations of cyclosporin A measured in plasma.样品制备对血浆中所测环孢素A浓度的影响。
Clin Chem. 1984 Nov;30(11):1812-4.
5
The value of serial serum trough cyclosporine levels in human renal transplantation.
Transplant Proc. 1984 Oct;16(5):1195-9.
6
Role of lipoproteins and erythrocytes in the in vitro binding and distribution of cyclosporin A in the blood.脂蛋白和红细胞在环孢素A于血液中的体外结合及分布中的作用。
J Pharm Pharmacol. 1982 Nov;34(11):715-8. doi: 10.1111/j.2042-7158.1982.tb06206.x.
7
Assessment of cyclosporin A in whole blood and plasma in five patients with different hematocrits.对五名血细胞比容不同的患者的全血和血浆中环孢素A的评估。
Ther Drug Monit. 1985;7(1):61-5. doi: 10.1097/00007691-198503000-00010.
8
Effect of hematocrit on cyclosporine (cyclosporin A) in whole blood and plasma of renal-transplant patients.血细胞比容对肾移植患者全血和血浆中环孢素（环孢素A）的影响。
Clin Chem. 1985 Mar;31(3):410-2.
9
The United Kingdom Cyclosporin Quality Assessment Scheme.英国环孢素质量评估计划。
Ther Drug Monit. 1986;8(2):200-4. doi: 10.1097/00007691-198606000-00013.
10
Temperature-dependent binding of cyclosporine to an erythrocyte protein.
Clin Chem. 1987 Apr;33(4):481-5.

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