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非水介质中脂质相变的结构与机制。熔融盐中的二棕榈酰磷脂酰乙醇胺。

Structures and mechanisms of lipid phase transitions in nonaqueous media. Dipalmitoylphosphatidylethanolamine in fused salt.

作者信息

Tamura-Lis W, Lis L J, Quinn P J

机构信息

Department of Physics, Kent State University, Ohio 44242.

出版信息

Biophys J. 1988 Apr;53(4):489-92. doi: 10.1016/S0006-3495(88)83127-8.

DOI:10.1016/S0006-3495(88)83127-8
PMID:3382708
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1330221/
Abstract

The phase transitions for dipalmitoylphosphatidylethanolamine (DPPE) dispersed in water and in N-ethylammonium nitrate (EAN) were examined using differential scanning calorimetry and time-resolved x-ray diffraction. Subgel, pre-, and main-phase transitions were observed for DPPE in water, whereas only the pre- and main transitions were observed for DPPE in EAN. Hysteresis was observed for both dispersions upon cooling. In addition, the lamellar (L alpha) to hexagonal (H alpha) phase transition was observed for DPPE dispersed in EAN when using time-resolved x-ray diffraction but not when using calorimetry. This low enthalpy process occurred at 73-77 degrees C, which is significantly lower than that observed for DPPE in water. The presence of EAN stabilizes the existence of the H alpha phase in DPPE by its influence on the bilayer interfacial properties, primarily on the area per lipid head group.

摘要

使用差示扫描量热法和时间分辨X射线衍射研究了分散在水中和硝酸N-乙基铵（EAN）中的二棕榈酰磷脂酰乙醇胺（DPPE）的相变。在水中观察到DPPE的亚凝胶相、预相变和主相变，而在EAN中仅观察到DPPE的预相变和主相变。冷却时两种分散体均观察到滞后现象。此外，使用时间分辨X射线衍射时，观察到分散在EAN中的DPPE从层状（Lα）到六方（Hα）相的转变，但使用量热法时未观察到。这个低焓过程发生在73-77摄氏度，明显低于在水中观察到的DPPE的转变温度。EAN的存在通过影响双层界面性质，主要是每个脂质头部基团的面积，稳定了DPPE中Hα相的存在。

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