从核DNA含量角度对南非人和日本人肝细胞癌的比较研究。
A comparative study on hepatocellular carcinoma between South Africans and Japanese from the viewpoint of nuclear DNA content.
作者信息
Yoshida Y, Kanematsu T, Matsumata T, Sugimachi K, Kew M C, Paterson A C
机构信息
Second Department of Surgery, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
出版信息
Br J Cancer. 1994 Feb;69(2):362-6. doi: 10.1038/bjc.1994.66.
Nuclear deoxyribonucleic acid (DNA) content of hepatocellular carcinoma (HCC) in 41 South African and 47 Japanese patients at autopsy was analysed by dual-wavelength microspectrophotometry. The DNA distribution patterns were classified as type I, II, III or IV and as low ploidy (types I, II) or high ploidy (types III, IV), according to the degree of dispersion. We found a significantly higher incidence of high ploidy in South African HCC than in Japanese HCC. Moreover, type IV was significantly more frequent among South Africans than among the Japanese. These findings demonstrate that large differences in biological characteristics and clinical behaviour of HCC between South Africa and Japan may reflect differences in DNA distribution patterns which we observed between these two races.
采用双波长显微分光光度法对41例南非患者和47例日本患者尸检时的肝细胞癌（HCC）细胞核脱氧核糖核酸（DNA）含量进行了分析。根据离散程度，DNA分布模式分为I型、II型、III型或IV型，以及低倍体（I型、II型）或高倍体（III型、IV型）。我们发现，南非HCC中高倍体的发生率显著高于日本HCC。此外，IV型在南非人中的出现频率明显高于日本人。这些发现表明，南非和日本之间HCC生物学特征和临床行为的巨大差异可能反映了我们在这两个种族之间观察到的DNA分布模式的差异。
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