内质网上的STING凝聚物限制干扰素反应。
STING condensates on ER limit IFN response.
作者信息
Andreeva Liudmila, Wu Hao
机构信息
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
出版信息
Nat Cell Biol. 2021 Apr;23(4):299-300. doi: 10.1038/s41556-021-00662-5.
Abstract
STING is a key player in the IFN response to cytosolic DNA, and its multimerization is commonly associated with activation of the pathway. A new study now shows that STING forms ‘puzzle’-like condensates to limit the IFN response and constrain antiviral immune activation.
摘要
STING是干扰素对胞质DNA反应中的关键因子，其多聚化通常与该信号通路的激活有关。一项新研究表明，STING会形成类似“拼图”的凝聚物，以限制干扰素反应并抑制抗病毒免疫激活。
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本文引用的文献
1
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Curr Opin Cell Biol. 2020 Apr;63:194-203. doi: 10.1016/j.ceb.2020.03.002. Epub 2020 Apr 6.
2
DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome.DDX3X 通过调节 NLRP3 炎性小体在应激细胞中充当生死检查点。
Nature. 2019 Sep;573(7775):590-594. doi: 10.1038/s41586-019-1551-2. Epub 2019 Sep 11.
3
Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP-AMP.冷冻电镜结构揭示了 STING 通过环鸟苷酸-腺苷酸激活的机制。
Nature. 2019 Mar;567(7748):389-393. doi: 10.1038/s41586-019-0998-5. Epub 2019 Mar 6.
4
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Nature. 2019 Mar;567(7748):394-398. doi: 10.1038/s41586-019-1000-2. Epub 2019 Mar 6.
5
DNA-induced liquid phase condensation of cGAS activates innate immune signaling.DNA 诱导的 cGAS 液-液相分离激活先天免疫信号转导。
Science. 2018 Aug 17;361(6403):704-709. doi: 10.1126/science.aat1022. Epub 2018 Jul 5.
6
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Nature. 2018 Jul;559(7713):269-273. doi: 10.1038/s41586-018-0287-8. Epub 2018 Jul 4.
7
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