Chauhan Ved, Anis Asaba, Chauhan Abha
New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA.
J Lipids. 2021 Mar 25;2021:5583114. doi: 10.1155/2021/5583114. eCollection 2021.
We studied the effects of starvation on changes in neutral lipids in male and female (fruit fly) at different ages. When flies were subjected to starvation, the mortality rate was observed to be age- and gender-dependent: male flies died earlier as compared to female flies, and older flies died earlier than younger flies. There was an increase in the number of dead flies and the levels of diacylglycerol (DG) with starvation time. This increase in DG was observed much earlier in male flies as compared to female flies, which correlated with earlier death in male flies during starvation in comparison to female flies. We also analyzed the levels of triglycerides (TG) and lipase activity during starvation of flies. The levels of TG decreased depending upon the duration of starvation in both male and female flies. Interestingly, we observed that like DG, there was also an increase in lipase activity due to starvation, which also correlated with earlier death in male flies as compared to female flies. Our results suggest that increase in DG levels and lipase activity due to starvation may be the main cause of death in the flies.
我们研究了饥饿对不同年龄的雄性和雌性（果蝇）中性脂质变化的影响。当果蝇遭受饥饿时，观察到死亡率与年龄和性别有关：与雌性果蝇相比，雄性果蝇死亡更早，且老龄果蝇比幼龄果蝇死亡更早。随着饥饿时间的延长，死亡果蝇的数量和二酰基甘油（DG）水平都有所增加。与雌性果蝇相比，雄性果蝇中DG的这种增加出现得更早，这与饥饿期间雄性果蝇比雌性果蝇更早死亡相关。我们还分析了果蝇饥饿期间甘油三酯（TG）水平和脂肪酶活性。在雄性和雌性果蝇中，TG水平均随着饥饿持续时间的延长而降低。有趣的是，我们观察到与DG一样，饥饿也会导致脂肪酶活性增加，这也与雄性果蝇比雌性果蝇更早死亡相关。我们的结果表明，饥饿导致的DG水平和脂肪酶活性增加可能是果蝇死亡的主要原因。
