车前草（）粉与磺胺嘧啶银对大鼠二度烧伤创面愈合的临床及组织病理学效果比较

The Comparison of Clinical and Histopathological Effects of Topical Psyllium () Powder and Silver Sulfadiazine on Second-Degree Burn Wound Healing in Rats.

作者信息

Jalilimanesh Mohammad, Azhdari Maryam, Mirjalili Aghdas, Mozaffari Mohammad Ali, Hekmatimoghaddam Seyedhossein

机构信息

Herbal Medicine Research Center, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

Department of Plastic and Reconstructive Surgery, Shohadaye Mehrab Hospital, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.

出版信息

World J Plast Surg. 2021 Jan;10(1):96-103. doi: 10.29252/wjps.10.1.96.

DOI:10.29252/wjps.10.1.96

PMID:33833960

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8016387/

Abstract

BACKGROUND

Burn wounds are a worldwide health problem, leading to physical and psychological disabilities in all age's groups. With regard to absorbent properties of mucilage which can decrease wound moisture, we aimed to compare the effect of silver sulfadiazine (SSD) 1% and powdered on second-degree burn wound healing in rats.

METHODS

This experimental study was conducted on 30 male Wistar rats with second-degree burn in three groups. Group 1 (control) did not receive any treatment; group 2 and group 3 (treated groups) were dressed daily using SSD cream and powder, respectively. The weight of rats, wound size (by applying ImageJ software) and percentage of wound healing on the 5, 7, 10, 13, 16, 19, and 22 days (by diagnosing a plastic surgeon) and histological cutaneous changes at day 22 were evaluated. The Prism software was applied for data analysis. The Haematoxylin & Eosin as well as Masson's trichrome staining were performed on wound skin biopsies.

RESULTS

On day 22, 20%, 50% and 60% of the rats had complete wound healing in the control, SSD and a groups, respectively. A significant decrease in wound size was shown in the treated groups compared to the control group (<0.01), but no significant difference was shown between the treated groups (>0.05).

CONCLUSION

However, the wound healing in group or SSD was better than the control group, and the significant difference was not found with the treated group.

摘要

背景

烧伤创面是一个全球性的健康问题，可导致所有年龄段人群出现身体和心理残疾。鉴于黏液的吸收特性可降低创面湿度，我们旨在比较1%磺胺嘧啶银（SSD）乳膏和粉剂对大鼠二度烧伤创面愈合的影响。

方法

本实验研究对30只雄性Wistar大鼠的二度烧伤创面进行分组研究。第1组（对照组）不接受任何治疗；第2组和第3组（治疗组）分别每日使用SSD乳膏和粉剂进行创面处理。评估大鼠体重、创面大小（通过ImageJ软件测量）以及在第5、7、10、13、16、19和22天的创面愈合百分比（由整形外科医生诊断），并在第22天评估皮肤组织学变化。使用Prism软件进行数据分析。对创面皮肤活检组织进行苏木精-伊红染色以及Masson三色染色。