Curlier Elodie, Fagour Laurence, Herrmann-Storck Cécile, Staelen Adrien, Vingadassalom Ingrid, Breurec Sébastien, Abel Sylvie, Pierre-François Sandrine, Jean-Marie Janick, Laouénan Cédric, Césaire Raymond, Hoen Bruno, Cabié André
Department of Infectious Diseases, CHU de la Guadeloupe, Pointe-à-Pitre, France.
INSERM Centre d'Investigation Clinique Antilles-Guyane, Cayenne, France.
PLoS Negl Trop Dis. 2021 Apr 9;15(4):e0009267. doi: 10.1371/journal.pntd.0009267. eCollection 2021 Apr.
In 2014, a first outbreak of chikungunya hit the Caribbean area where chikungunya virus (CHIKV) had never circulated before.
METHODOLOGY/PRINCIPAL FINDINGS: We conducted a cross-sectional study to measure the seroprevalence of CHIKV immediately after the end of the 2014 outbreak in HIV-infected people followed up in two clinical cohorts at the University hospitals of Guadeloupe and Martinique. Study patients were identified during the first months of 2015 and randomly selected to match the age and sex distribution of the general population in the two islands. They were invited to complete a survey that explored the symptoms consistent with chikungunya they could have developed during 2014 and to have a blood sample drawn for CHIKV serology. The study population consisted of 377 patients (198 in Martinique and 179 in Guadeloupe, 178 men and 199 women), 182 of whom reported they had developed symptoms consistent with chikungunya. CHIKV serology was positive in 230 patients, which accounted for an overall seroprevalence rate of 61% [95%CI 56-66], with only 153 patients who reported symptoms consistent with chikungunya. Most frequent symptoms included arthralgia (94.1%), fever (73.2%), myalgia (53.6%), headache (45.8%), and skin rash (26.1%).
CONCLUSIONS/SIGNIFICANCE: This study showed that the seroprevalence of CHIKV infection was 61% after the 2014 outbreak, with one third of asymptomatic infections.
ClinicalTrials.gov NCT02553369.
2014年，基孔肯雅热首次在加勒比地区爆发，而此前基孔肯雅病毒（CHIKV）从未在该地区传播过。
方法/主要发现：我们开展了一项横断面研究，以测量2014年疫情结束后，在瓜德罗普岛和马提尼克岛大学医院的两个临床队列中接受随访的HIV感染者中CHIKV的血清阳性率。研究对象于2015年的头几个月确定，并随机选取以匹配两个岛屿普通人群的年龄和性别分布。邀请他们完成一项调查，该调查探讨了他们在2014年期间可能出现的与基孔肯雅热相符的症状，并采集血样进行CHIKV血清学检测。研究人群包括377名患者（马提尼克岛198名，瓜德罗普岛179名，男性178名，女性199名），其中182人报告出现了与基孔肯雅热相符的症状。230名患者的CHIKV血清学检测呈阳性，总体血清阳性率为61%[95%置信区间56 - 66]，其中只有153名患者报告出现了与基孔肯雅热相符的症状。最常见的症状包括关节痛（94.1%）、发热（73.2%）、肌痛（53.6%）、头痛（45.8%）和皮疹（26.1%）。
结论/意义：本研究表明，2014年疫情后CHIKV感染的血清阳性率为61%，其中三分之一为无症状感染。
ClinicalTrials.gov NCT02553369。
