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纳米颗粒在 COVID-19 中的靶向作用：诊断与治疗。

Focused role of nanoparticles against COVID-19: Diagnosis and treatment.

机构信息

School of Physics, Universiti Sains Malaysia, 11800, Pulau, Pinang, Malaysia; Nano-Biotechnology Research and Innovation (NanoBRI), Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau, Pinang, Malaysia.

School of Physics, Universiti Sains Malaysia, 11800, Pulau, Pinang, Malaysia; Department of Radiology and Molecular Imaging, College of Medicine and Health Science, Sultan Qaboos University. PO. Box: 35, 123, Al Khod, Muscat, Oman.

出版信息

Photodiagnosis Photodyn Ther. 2021 Jun;34:102287. doi: 10.1016/j.pdpdt.2021.102287. Epub 2021 Apr 6.

DOI:10.1016/j.pdpdt.2021.102287
PMID:33836276
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8022514/
Abstract

The 2019 novel coronavirus (2019-nCoV; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) has witnessed a rapid and global proliferation since its early identification in patients with severe pneumonia in Wuhan, China. As of 27th May 2020, 2019-nCoV cases have risen to >5 million, with confirmed deaths of 350,000. However, Coronavirus disease (COVID-19) diagnostic and treatment measures are yet to be fully unraveled, given the novelty of this particular coronavirus. Therefore, existing antiviral agents used for severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV) were repurposed for COVID-19, taking their biological features into consideration. This study provides a concise review of the current and emerging detection and supervision technologies for SARS-CoV-2, which is the viral etiology of COVID19, and their performance characteristics, with emphasis on the novel Nano-based diagnostic tests (protein corona sensor array and magnetic levitation) and treatment measures (treatment protocols based on nano-silver colloids) for COVID-19.

摘要

自 2019 年新型冠状病毒（2019-nCoV；严重急性呼吸综合征冠状病毒 2（SARS-CoV-2））在中国武汉的重症肺炎患者中早期鉴定以来，其迅速在全球范围内传播。截至 2020 年 5 月 27 日，2019-nCoV 病例已上升至超过 500 万例，确诊死亡人数为 35 万。然而，由于这种特定冠状病毒的新颖性，冠状病毒疾病（COVID-19）的诊断和治疗措施尚未完全阐明。因此，考虑到严重急性呼吸综合征冠状病毒（SARS-CoV）和中东呼吸综合征冠状病毒（MERS-CoV）的现有抗病毒药物被重新用于 COVID-19，同时考虑到它们的生物学特征。本研究简要综述了目前和新兴的 SARS-CoV-2 检测和监测技术，以及它们的性能特征，重点介绍了新型基于纳米的诊断测试（蛋白冠传感器阵列和磁悬浮）和 COVID-19 的治疗措施（基于纳米银胶体的治疗方案）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/c7e040736894/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/fa1628eb3cef/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/7f5bbaeada89/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/d2193935d4e4/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/00a86813bea3/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/9ed136765fff/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/c7e040736894/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/fa1628eb3cef/ga1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/7f5bbaeada89/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/d2193935d4e4/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/00a86813bea3/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/9ed136765fff/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3535/8022514/c7e040736894/gr5_lrg.jpg

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