Center for Integrated Human Brain Science, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata, 951-8585, Japan.
Cognitive Neuroscience Section, Primate Research Institute, Kyoto University, 41-2, Kanrin, Inuyama, Aichi, 484-8506, Japan.
Hear Res. 2021 Jun;405:108229. doi: 10.1016/j.heares.2021.108229. Epub 2021 Mar 27.
The common marmoset (Callithrix jacchus), a New World monkey, serves as a useful animal model in clinical and basic neuroscience. The present study recorded scalp auditory evoked potentials (AEP) in non-sedated common marmoset monkeys (n = 4) using a noninvasive method similar to that used in humans, and aimed to identify nonhuman primate correlates of the human AEP components. A pure tone stimulus was presented while electroencephalograms were recorded using up to 16 disk electrodes placed on the scalp and earlobes. Candidate homologues of two categories of the human AEP, namely, the middle latency responses (MLR; Na, Pa, Nb, and Pb) and the cortical auditory evoked potentials (CAEP; P1, N1, P2, N2, and the sustained potential, SP) were identified in the marmoset. These waves were labeled as CjNa, CjPa, CjNb, CjPb, CjP1, CjN1, CjP2, CjN2, and CjSP, where Cj stands for Callithrix jacchus. The last MLR component, CjPb, was identical to the first CAEP component, CjP1, similar to the relationship between Pb and P1 in humans. The peak latencies of the marmoset MLR and CAEP were generally shorter than in humans, which suggests a shorter integration time in neural processing. To our knowledge, the present study represents the first scalp recorded MLR and CAEP in the alert common marmoset. Further use of these recording methods would enable valid species comparisons of homologous brain indices between humans and animals.
普通狨猴（Callithrix jacchus）是新世界猴，是临床和基础神经科学的有用动物模型。本研究采用类似于人类的非侵入性方法，在未镇静的普通狨猴（n=4）中记录头皮听觉诱发电位（AEP），旨在确定非人灵长类动物与人类 AEP 成分的对应关系。使用多达 16 个放置在头皮和耳垂上的圆盘电极记录脑电图，同时呈现纯音刺激。在狨猴中，确定了人类 AEP 的两个类别（中间潜伏期反应（MLR；Na、Pa、Nb 和 Pb）和皮质听觉诱发电位（CAEP；P1、N1、P2、N2 和持续电位，SP）的候选同源物。这些波被标记为 CjNa、CjPa、CjNb、CjPb、CjP1、CjN1、CjP2、CjN2 和 CjSP，其中 Cj 代表 Callithrix jacchus。最后一个 MLR 成分 CjPb 与第一个 CAEP 成分 CjP1 相同，类似于人类 Pb 和 P1 之间的关系。狨猴 MLR 和 CAEP 的峰潜伏期普遍短于人类，这表明神经处理中的整合时间更短。据我们所知，本研究代表了在警觉的普通狨猴中首次记录的头皮 MLR 和 CAEP。进一步使用这些记录方法可以在人类和动物之间对同源脑指数进行有效的物种比较。
