Cognitive Neuroscience Section, Primate Research Institute, Kyoto University, Aichi, 484-8506, Japan.
Center for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan.
Sci Rep. 2022 Jun 2;12(1):9210. doi: 10.1038/s41598-022-13228-8.
Auditory steady-state responses (ASSRs) are basic neural responses used to probe the ability of auditory circuits to produce synchronous activity to repetitive external stimulation. Reduced ASSR has been observed in patients with schizophrenia, especially at 40 Hz. Although ASSR is a translatable biomarker with a potential both in animal models and patients with schizophrenia, little is known about the features of ASSR in monkeys. Herein, we recorded the ASSR from humans, rhesus monkeys, and marmosets using the same method to directly compare the characteristics of ASSRs among the species. We used auditory trains on a wide range of frequencies to investigate the suitable frequency for ASSRs induction, because monkeys usually use stimulus frequency ranges different from humans for vocalization. We found that monkeys and marmosets also show auditory event-related potentials and phase-locking activity in gamma-frequency trains, although the optimal frequency with the best synchronization differed among these species. These results suggest that the ASSR could be a useful translational, cross-species biomarker to examine the generation of gamma-band synchronization in nonhuman primate models of schizophrenia.
听觉稳态反应（ASSR）是一种基本的神经反应，用于探测听觉回路产生对外界刺激重复同步活动的能力。在精神分裂症患者中观察到 ASSR 降低，特别是在 40Hz 时。尽管 ASSR 是一种具有转化潜力的生物标志物，无论是在动物模型还是精神分裂症患者中，关于猴子的 ASSR 特征知之甚少。在此，我们使用相同的方法从人类、恒河猴和狨猴记录 ASSR，直接比较这些物种之间 ASSR 的特征。我们使用广泛频率的听觉序列来研究 ASSR 诱导的合适频率，因为猴子通常使用与人类不同的刺激频率范围进行发声。我们发现，猴子和狨猴也在伽马频带序列中表现出听觉事件相关电位和相位锁定活动，尽管这些物种的最佳同步频率不同。这些结果表明，ASSR 可能是一种有用的转化、跨物种生物标志物，可用于检查精神分裂症非人类灵长类模型中伽马带同步的产生。
