Dun Yaojun, Shi Yi, Guo Hongwei, Liu Yanxiang, Qian Xiangyang, Sun Xiaogang, Yu Cuntao
Department of Cardiovascular Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
J Thorac Dis. 2021 Mar;13(3):1531-1542. doi: 10.21037/jtd-20-3081.
There are limited data regarding the clinical outcomes of reoperative aortic root or ascending aorta replacement after prior aortic valve replacement (AVR). We aimed to analyze outcomes of reoperative aortic root or ascending aorta replacement after prior AVR.
Eighty patients with prior AVR underwent reoperative aortic root or ascending aorta replacement in our hospital. The indications were root or ascending aortic aneurysm in 36 patients, root or ascending aortic dissection in 37, root false aneurysm in 2, prosthesis valve endocarditis (PVE) with root abscess in 2, Behçet's disease (BD) with root destruction in 3 patients. An elective surgery was performed in 63 patients and an emergent surgery in 17. The survival and freedom from aortic events during the follow-up were evaluated with the Kaplan-Meier survival curve and the log-rank test.
The operative techniques included ascending aorta replacement in 14 patients, ascending aorta replacement with AVR in 3, prosthesis-sparing root replacement (PSRR) in 35, Bentall procedure in 24, and Cabrol procedure in 4 patients. Operative mortality was 1.3% (1/80). A composite of adverse events occurred in 5 patients, including 1 operative death, 2 stroke and 3 renal failure necessitating hemodialysis. The mean follow-up was 35.5±22.1 months. Five late deaths occurred. The Kaplan-Meier survival at 1 year, 3 years and 6 years were 97.5%, 91.1% and 84.1%, respectively. Aortic events developed in 3 patients. The freedom from aortic events at 1-year, 3-year, and 6-year were 100%, 96.3% and 88.9%, respectively. There were no differences in survival and freedom from aortic events between the elective group and the emergent group.
Reoperative aortic root or ascending aorta replacement after prior AVR could be performed to treat the root or ascending pathologies after AVR, with satisfactory early and midterm outcomes.
关于先前进行主动脉瓣置换术(AVR)后再次进行主动脉根部或升主动脉置换术的临床结果的数据有限。我们旨在分析先前进行AVR后再次进行主动脉根部或升主动脉置换术的结果。
80例先前接受过AVR的患者在我院接受了再次主动脉根部或升主动脉置换术。适应证包括36例根部或升主动脉瘤、37例根部或升主动脉夹层、2例根部假性动脉瘤、2例伴有根部脓肿的人工瓣膜心内膜炎(PVE)、3例患有根部破坏的白塞病(BD)。63例患者进行了择期手术,17例进行了急诊手术。采用Kaplan-Meier生存曲线和对数秩检验评估随访期间的生存率和无主动脉事件生存率。
手术技术包括14例升主动脉置换术、3例升主动脉置换联合AVR、35例保留人工瓣膜的根部置换术(PSRR)、24例Bentall手术和4例Cabrol手术。手术死亡率为1.3%(1/80)。5例患者发生了不良事件的复合情况,包括1例手术死亡、2例中风和3例需要血液透析的肾衰竭。平均随访时间为35.5±22.1个月。发生了5例晚期死亡。1年、3年和6年的Kaplan-Meier生存率分别为97.5%、91.1%和84.1%。3例患者发生了主动脉事件。1年、3年和6年的无主动脉事件生存率分别为100%、96.3%和88.9%。择期组和急诊组在生存率和无主动脉事件生存率方面没有差异。
先前进行AVR后再次进行主动脉根部或升主动脉置换术可用于治疗AVR后的根部或升主动脉病变,早期和中期结果令人满意。