Rojas Patricio, Sarmiento Mauricio
Departamento de Hematología y Oncología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Rev Med Chil. 2020 Nov;148(11):1640-1646. doi: 10.4067/S0034-98872020001101640.
The pathophysiology of the inflammatory profile induced by SARS-COV2 infection has similarities with conditions of immune system activation with cytokine release such as hemophagocytic syndrome and some cases of acute graft-versus-host disease. There are encouraging results of clinical studies, performed with increasingly better methodological quality, supporting the use of targeted and specific anti-inflammatory therapy in selected groups of patients with COVID-19 with severe inflammation. In this review we describe the inflammatory pathophysiology of the disease and the recent findings about its treatment.
由SARS-CoV-2感染引起的炎症反应的病理生理学与免疫系统激活伴细胞因子释放的情况相似，如噬血细胞综合征和某些急性移植物抗宿主病病例。临床研究取得了令人鼓舞的结果，研究方法质量越来越高，支持在选定的患有严重炎症的COVID-19患者群体中使用靶向性和特异性抗炎治疗。在这篇综述中，我们描述了该疾病的炎症病理生理学及其治疗的最新发现。
