视网膜静脉阻塞患者血管密度测量的可重复性：光学相干断层扫描血管造影研究。
Repeatability of measuring the vessel density in patients with retinal vein occlusion: An optical coherence tomography angiography study.
机构信息
Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Department of Ophthalmology, Konyang University College of Medicine, Daejeon, Republic of Korea.
出版信息
PLoS One. 2020 Jun 25;15(6):e0234933. doi: 10.1371/journal.pone.0234933. eCollection 2020.
PURPOSE
To determine the repeatability of superficial vessel density measurements using Spectral domain Ocular coherence tomography angiography(SD-OCTA) in patients diagnosed with retinal vein occlusion(RVO).
DESIGN
Prospective observational study.
SUBJECTS
Patients who visited our retinal clinic from August 2017 to August 2018, diagnosed with RVO were recruited for the study.
METHODS
Two consecutive 3×3 mm pattern scans were performed using the Cirrus HD-OCT 5000 along with AngioPlex software (Carl Zeiss Meditec) in each eye by single skilled examiner. All scans were analyzed using en face OCTA images to measure vessel density (VD) automatically. For further analysis of the effect of central macular thickness(CMT), eyes were divided into two groups according to CMT of 400μm (Group 1: CMT > 400μm, Group 2: CMT < 400μm). To identify factors affecting the repeatability of VD measurements, linear regression analyses were conducted for the coefficient of variation (CV) of VD by investigating demographics and ocular variables.
MAIN OUTCOME MEASURES
The intraclass correlation coefficient (ICC), coefficient of variation (CV) of VD measurements.
RESULTS
A total of 57 eyes from 57 patients were examined: 35 eyes with BRVO and 22 eyes with CRVO. In all 57 eyes with RVO, the ICC and CV of the full VD(VD of 3mm diameter circle) were 0.800 and 10.61%, respectively. Univariate analyses showed that the mean CMT (B, 0.001; p<0.001) and mean ganglion cell-Inner plexiform layer (GC-IPL) thickness (B, -0.002; p = 0.020) were significant factors that affected the repeatability. Multivariate analyses of these two factors showed that only mean CMT was a significant factor. The ICC and CV of the full VD in group 1 (CMT > 400μm) were 0.348 and 22.55% respectively. In group 2 (CMT < 400μm), the ICC and CV of the full VD were 0.910 and 7.76%, respectively.
CONCLUSIONS
The repeatability of VD measurement in eyes with RVO was reasonably comparable to previous studies. Repeatability of VD measurement was significantly affected by central macular thickness.
目的
使用谱域光相干断层扫描血管造影术（SD-OCTA）确定诊断为视网膜静脉阻塞（RVO）患者的浅层血管密度测量的重复性。
设计
前瞻性观察研究。
受试者
2017 年 8 月至 2018 年 8 月期间在我院视网膜门诊就诊，诊断为 RVO 的患者入选本研究。
方法
由一名熟练的检查者对每只眼连续进行两次 3×3mm 模式扫描，使用 Cirrus HD-OCT 5000 结合 AngioPlex 软件（卡尔蔡司医学技术公司）进行。所有扫描均使用基于 Enface 的 OCTA 图像自动分析以测量血管密度（VD）。为了进一步分析中央黄斑厚度（CMT）的影响，根据 CMT 分为 400μm 将眼分为两组（组 1：CMT＞400μm，组 2：CMT＜400μm）。为了确定影响 VD 测量重复性的因素，通过调查人口统计学和眼部变量，对 VD 的变异系数（CV）进行线性回归分析。
主要观察指标
内类相关系数（ICC），VD 测量的变异系数（CV）。
结果
共检查了 57 例 57 只眼：35 只眼为 BRVO，22 只眼为 CRVO。在所有 57 只 RVO 眼中，全 VD（3mm 直径圆的 VD）的 ICC 和 CV 分别为 0.800 和 10.61%。单变量分析显示，平均 CMT（B，0.001；p＜0.001）和平均神经节细胞-内丛状层（GC-IPL）厚度（B，-0.002；p=0.020）是影响重复性的显著因素。对这两个因素的多变量分析显示，只有平均 CMT 是一个显著因素。组 1（CMT＞400μm）全 VD 的 ICC 和 CV 分别为 0.348 和 22.55%。在组 2（CMT＜400μm）中，全 VD 的 ICC 和 CV 分别为 0.910 和 7.76%。
结论
RVO 患者 VD 测量的重复性与先前的研究相当。VD 测量的重复性受中央黄斑厚度的显著影响。
Zotero 插件