Lee Min-Woo, Kim Kyeung-Min, Lim Hyung-Bin, Jo Young-Joon, Kim Jung-Yeul
Department of Ophthalmology, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Department of Ophthalmology, Armed Forces Capital Hospital, Seongnam, Republic of Korea.
Br J Ophthalmol. 2018 Jul 4. doi: 10.1136/bjophthalmol-2018-312516.
To analyse the repeatability of vessel density (VD) measurements using optical coherence tomography angiography (OCTA) in patients with retinal diseases.
Two consecutive VD measurements using OCTA were analysed prospectively in patients with retinal diseases (diabetic macular oedema (DME), retinal vein occlusion (RVO) with macular oedema, epiretinal membrane (ERM), wet age-related macular degeneration (AMD)). The intraclass correlation coefficient (ICC), coefficient of variation (CV) and test-retest SD of VD measurements were assessed, and linear regression analyses were conducted to identify factors related to repeatability.
A total of 134 eyes were analysed involving 20 eyes with DME, 44 eyes with RVO with macular oedema, 50 eyes with ERM and 20 eyes with wet AMD. The mean age was 64.9 years, and the mean best-corrected visual acuity (BCVA) was 0.24. The mean central macular thickness (CMT) was 391.6 µm, and the mean ganglion cell-inner plexiform layer (GC-IPL) thickness was 61.4 µm. In all four diseases, the ICC and CV of the full VD were 0.812 and 6.72%, respectively. Univariate analyses showed that the BCVA (B, 8.553; p=0.031), signal strength (B, -1.688; p=0.050), CMT (B, 0.019; p=0.015) and mean GC-IPL thickness (B, -0.103; p=0.001) were significant factors that affected the repeatability. Multivariate analyses of these factors showed a significant result for the GC-IPL thickness.
Measurements of the VD using OCTA showed relatively good repeatability for various retinal diseases. The BCVA, signal strength, CMT and GC-IPL thickness affected the repeatability, so these factors should be considered when analysing the VD.
分析光学相干断层扫描血管造影（OCTA）测量视网膜疾病患者血管密度（VD）的可重复性。
对视网膜疾病（糖尿病性黄斑水肿（DME）、伴有黄斑水肿的视网膜静脉阻塞（RVO）、视网膜前膜（ERM）、湿性年龄相关性黄斑变性（AMD））患者，前瞻性分析连续两次使用OCTA测量VD的情况。评估VD测量的组内相关系数（ICC）、变异系数（CV）和重测标准差，并进行线性回归分析以确定与可重复性相关的因素。
共分析134只眼，其中20只眼患有DME，44只眼患有伴有黄斑水肿的RVO，50只眼患有ERM，20只眼患有湿性AMD。平均年龄为64.9岁，平均最佳矫正视力（BCVA）为0.24。平均中心黄斑厚度（CMT）为391.6 µm，平均神经节细胞-内丛状层（GC-IPL）厚度为61.4 µm。在所有四种疾病中，全层VD的ICC和CV分别为0.812和6.72%。单因素分析显示，BCVA（B，8.553；p = 0.031）、信号强度（B，-1.688；p = 0.050）、CMT（B，0.019；p = 0.015）和平均GC-IPL厚度（B，-0.103；p = 0.001）是影响可重复性的显著因素。对这些因素进行多因素分析显示，GC-IPL厚度有显著结果。
使用OCTA测量VD对各种视网膜疾病显示出相对较好的可重复性。BCVA、信号强度、CMT和GC-IPL厚度影响可重复性，因此在分析VD时应考虑这些因素。
