Department of Ophthalmology, Semmelweis University, 26 Üllői Street, 1085, Budapest, Hungary.
Sci Rep. 2018 Jul 13;8(1):10598. doi: 10.1038/s41598-018-28994-7.
In clinical practice the measurement error of an instrument has special importance in analyzing and interpreting data, and acknowledging limitations. The purpose of this study was to evaluate intrasession and between-visit reproducibility of OCT angiography measurements in diabetic patients. A total of 54 eyes of 27 diabetic patients underwent OCT angiography imaging. Foveal avascular zone (FAZ) area and superficial retinal vessel density (VD) at 3 mm were calculated using the AngioAnalytics software. Three consecutive images were acquired at first visit and one image 1 month later. Intrasession and between-visit reproducibility of parameters were characterized by intraclass correlation coefficient (ICC), coefficient of variation (CV), and coefficient of repeatability (CR) values. We measured excellent (>0.90) ICC values both in intrasession and between-visit comparisons. CV was higher for the FAZ area compared to VD both in intrasession (7.79% vs. 2.87%) and in between-visit (12.33% vs. 2.95%) comparisons. Between-visit CR value for VD was 4.53% (95% CI: 3.72-5.79%). These data suggest that OCT angiography shows excellent repeatability in diabetic patients, indicating that this non-invasive technology might be suitable for longitudinal assessment of microvascular complications.
在临床实践中，仪器的测量误差在分析和解释数据以及承认局限性方面具有特殊意义。本研究旨在评估糖尿病患者的 OCT 血管造影测量的日内和间访重现性。共有 27 名糖尿病患者的 54 只眼接受了 OCT 血管造影成像。使用 AngioAnalytics 软件计算黄斑无血管区（FAZ）面积和 3mm 处的浅层视网膜血管密度（VD）。首次就诊时采集了三个连续的图像，一个月后采集了一个图像。参数的日内和间访重现性通过组内相关系数（ICC）、变异系数（CV）和可重复性系数（CR）值来描述。我们在日内和间访比较中均测量到了优异的（>0.90）ICC 值。与 VD 相比，FAZ 区域的 CV 在日内（7.79%比 2.87%）和间访（12.33%比 2.95%）比较中均更高。VD 的间访 CR 值为 4.53%（95%CI：3.72-5.79%）。这些数据表明，OCT 血管造影在糖尿病患者中具有出色的可重复性，表明这种非侵入性技术可能适合于微血管并发症的纵向评估。
