Perticone Maria, Maio Raffaele, Caroleo Benedetto, Suraci Edoardo, Corrao Salvatore, Sesti Giorgio, Perticone Francesco
Department of Medical and Surgical Sciences, University Magna Græcia, Viale Europa-Loc. Germaneto, 88100, Catanzaro, Italy.
Azienda Ospedaliero-Universitaria Mater Domini, Catanzaro, Italy.
Sci Rep. 2021 Apr 12;11(1):7884. doi: 10.1038/s41598-021-86963-z.
Essential hypertension and chronic obstructive pulmonary disease often coexist in the same patient. The aim of this study was to evaluate whether the addition of chronic obstructive pulmonary disease modifies the risk of cardiovascular events in hypertensives. We enrolled 1728 hypertensives. Study outcomes included fatal and non-fatal cardiovascular stroke and myocardial infarction, and cardiovascular death. During a mean follow-up of 57 months there were 205 major adverse cardiovascular events (2.47 per 100 pts/yr): cardiac (n117; 1.41 per 100 pts/yr) and cerebrovascular (n = 77; 0.93 per 100 pts/yr). In hypertensives with chronic obstructive pulmonary disease we observed a greater number of cardiovascular events than in hypertensives without respiratory disease (133 [5.55 per 100 pts/yr) vs 72 [1.22 per 100 pts/yr], respectively. The addition of chronic obstructive pulmonary disease to hypertension increased the incidence of total and non-fatal stroke of more than nine- (2.42 vs 0.32 per 100 pts/yr) and 11-fold (2.09 vs 0.22 per 100 pts/yr), respectively. The same trend was observed for total (2.88 vs 0.81 per 100 pts/yr) and non-fatal (2.67 vs 0.79 per 100 pts/y) myocardial infarction. The presence of chronic obstructive pulmonary disease in hypertensives significantly increases the risk of stroke, myocardial infarction and major adverse cardiovascular events.
原发性高血压和慢性阻塞性肺疾病常并存于同一患者。本研究的目的是评估合并慢性阻塞性肺疾病是否会改变高血压患者发生心血管事件的风险。我们纳入了1728例高血压患者。研究结局包括致命和非致命性心血管卒中、心肌梗死以及心血管死亡。在平均57个月的随访期间，共发生205例主要不良心血管事件（每100例患者每年2.47例）：心脏事件（n = 117；每100例患者每年1.41例）和脑血管事件（n = 77；每100例患者每年0.93例）。在合并慢性阻塞性肺疾病的高血压患者中，我们观察到的心血管事件数量多于无呼吸系统疾病的高血压患者（分别为133例[每100例患者每年5.55例]和72例[每100例患者每年1.22例]）。高血压合并慢性阻塞性肺疾病使总卒中及非致命性卒中的发生率分别增加了9倍多（每100例患者每年2.42例 vs 0.32例）和11倍（每100例患者每年2.09例 vs 0.22例）。总心肌梗死（每100例患者每年2.88例 vs 0.81例）和非致命性心肌梗死（每100例患者每年2.67例 vs 0.79例）也观察到同样的趋势。高血压患者合并慢性阻塞性肺疾病会显著增加卒中、心肌梗死和主要不良心血管事件的风险。
