Department of Pharmacology, Faculty of Dentistry, Near East University, Nicosia 99138, Cyprus.
Department of Endodontics, Faculty of Dentistry, Near East University, Nicosia 99138, Cyprus.
Med Hypotheses. 2021 Jun;151:110588. doi: 10.1016/j.mehy.2021.110588. Epub 2021 Mar 30.
Daily new information emerges regarding the COVID-19, infection of SARS-CoV-2, which is considered a global pandemic. Angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2) are required to complete the viral invasion pathway and are present in the oral mucosa, gingiva and periodontal pocket. Thus, increasing the likelihood of periodontitis and gingivitis caused by COVID-19. The cytokine storm during COVID-19 similarly arises during periodontal inflammation. Studies have reported that NOD-Like Receptor family pyrin domain-containing 3 (NLRP3) inflammasome is significant in the cytokine storm. Recently, the course of the COVID-19 has been related to the melatonin levels in both COVID-19 and periodontal diseases. It is known that melatonin prevents the activation of NLRP3 inflammasome. In light of these findings, we think that melatonin treatment during COVID-19 or periodontal diseases may prevent the damage seen in periodontal tissues by preventing the activation of NLRP3 inflammasome.
关于 COVID-19，即严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染的每日新信息不断涌现，这被认为是一种全球大流行疾病。血管紧张素转换酶 2（ACE2）和跨膜丝氨酸蛋白酶 2（TMPRSS2）是完成病毒入侵途径所必需的，存在于口腔黏膜、牙龈和牙周袋中。因此，增加了 COVID-19 引起牙周炎和牙龈炎的可能性。COVID-19 期间的细胞因子风暴同样也会在牙周炎症期间发生。研究报告称，NOD 样受体家族含 pyrin 结构域蛋白 3（NLRP3）炎症小体在细胞因子风暴中具有重要作用。最近，COVID-19 的病程与 COVID-19 和牙周病中的褪黑素水平有关。已知褪黑素可防止 NLRP3 炎症小体的激活。鉴于这些发现，我们认为在 COVID-19 或牙周病期间进行褪黑素治疗可能通过防止 NLRP3 炎症小体的激活来预防牙周组织的损伤。
