Hui S L, Slemenda C W, Johnston C C
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202.
J Clin Invest. 1988 Jun;81(6):1804-9. doi: 10.1172/JCI113523.
To study the effect of bone mass on the risk of fracture, we followed 521 Caucasian women over an average of 6.5 yr and took repeated bone mass measurements at the radius. We observed 138 nonspinal fractures in 3,388 person-yr. The person-years of follow-up and the incident fractures were cross-classified by age and bone mass. The incidence of fracture was then fitted to a log-linear model in age and bone mass. It was found that incidence of fracture increased with both increasing age and decreasing radius bone mass. When subsets of fractures were examined it was found that age was a stronger predictor of hip fractures, whereas midshaft radius bone mass was a stronger predictor of fractures at the distal forearm. We concluded that bone mass is a useful predictor of fractures but that other age-related factors associated with fractures need to be identified.
为研究骨量对骨折风险的影响，我们对521名白种女性进行了平均6.5年的随访，并对桡骨进行了多次骨量测量。在3388人年中，我们观察到138例非脊柱骨折。随访的人年数和新发骨折按年龄和骨量进行交叉分类。然后将骨折发生率拟合到年龄和骨量的对数线性模型中。结果发现，骨折发生率随年龄的增加和桡骨骨量的减少而增加。当对骨折亚组进行检查时发现，年龄是髋部骨折更强的预测因素，而桡骨中段骨量是前臂远端骨折更强的预测因素。我们得出结论，骨量是骨折的一个有用预测指标，但还需要确定与骨折相关的其他年龄相关因素。
