Department of Chemical Engineering, University of Washington, Seattle, Washington 98115, USA; email:
Molecular Engineering and Sciences Institute, University of Washington, Seattle, Washington 98115, USA.
Annu Rev Chem Biomol Eng. 2021 Jun 7;12:333-357. doi: 10.1146/annurev-chembioeng-102020-015923. Epub 2021 Apr 14.
There is considerable interest in the development of hybrid organic-inorganic materials because of the potential for harvesting the unique capabilities that each system has to offer. Proteins are an especially attractive organic component owing to the high amount of chemical information encoded in their amino acid sequence, their amenability to molecular and computational (re)design, and the many structures and functions they specify. Genetic installation of solid-binding peptides (SBPs) within protein frameworks affords control over the position and orientation of adhesive and morphogenetic segments, and a path toward predictive synthesis and assembly of functional materials and devices, all while harnessing the built-in properties of the host scaffold. Here, we review the current understanding of the mechanisms through which SBPs bind to technologically relevant interfaces, with an emphasis on the variables that influence the process, and highlight the last decade of progress in the use of solid-binding proteins for hybrid and hierarchical materials synthesis.
由于可以利用每个系统所提供的独特功能，因此开发混合有机-无机材料引起了相当大的兴趣。蛋白质是一种特别有吸引力的有机成分，因为它们的氨基酸序列中编码了大量的化学信息，并且易于进行分子和计算（再）设计，以及它们指定的许多结构和功能。在蛋白质框架内遗传安装固着肽（SBP）可以控制粘合和形态发生片段的位置和方向，并为功能材料和设备的预测合成和组装提供途径，同时利用宿主支架的内置特性。在这里，我们回顾了当前对 SBP 与技术相关界面结合机制的理解，重点介绍了影响该过程的变量，并强调了过去十年中使用固着蛋白进行混合和分层材料合成的进展。
