重组人肿瘤坏死因子可导致小鼠食物摄入量和体重急剧下降。
Recombinant human tumor necrosis factor induces acute reductions in food intake and body weight in mice.
作者信息
Socher S H, Friedman A, Martinez D
机构信息
Department of Cancer Research, Merck Sharp & Dohme Research Laboratories, West Point, Pennsylvania 19486.
出版信息
J Exp Med. 1988 Jun 1;167(6):1957-62. doi: 10.1084/jem.167.6.1957.
Abstract
We examined the effects of treatment with rHuTNF on food consumption and body weight in C3H/HeJ mice. rHuTNF was administered intraperitoneally either by injections of 3, 12, or 24 micrograms twice a day or by implantation of osmotic pumps that released 0.75, 3, or 12 micrograms per day. Dose-dependent reductions in both food intake and weight were induced by rHuTNF. However, in spite of continued exposure to rHuTNF, the mice developed a resistance to rHuTNF and resumed their pretreatment food intake and weight. Non-immunological factors may play a role in the development of this tolerance, since it developed rapidly and faded within 2 wk of cessation of exposure to rHuTNF.
摘要
我们研究了重组人肿瘤坏死因子（rHuTNF）治疗对C3H/HeJ小鼠食物消耗和体重的影响。rHuTNF通过每天两次注射3、12或24微克或植入每天释放0.75、3或12微克的渗透泵进行腹腔给药。rHuTNF诱导了食物摄入量和体重的剂量依赖性降低。然而，尽管持续接触rHuTNF，小鼠对rHuTNF产生了抗性，并恢复了预处理时的食物摄入量和体重。非免疫因素可能在这种耐受性的发展中起作用，因为它发展迅速且在停止接触rHuTNF后2周内消退。
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