Nwonuma C O, Osemwegie O O, Alejolowo O O, Irokanulo E O, Olaniran A F, Fadugba D O, Opaleke D O, Ojo O A
Department of Biochemistry, Landmark University, Omu-aran, Nigeria.
Department of Microbiology, Landmark University, Omu-aran, Nigeria.
Toxicol Rep. 2021 Mar 31;8:759-766. doi: 10.1016/j.toxrep.2021.03.029. eCollection 2021.
Linn (Onion) Organosulfuric compounds and phytonutrients have medicinal benefits. The study estimated the antioxidant effect of in fortified feed against oxidative damage caused by potassium bromate. Commercial feed was fortified by substituting 10 %, 20 %, and 30 % of rat's daily ration with the respective portion of pulverized . Potassium bromate was administered orally to the rats in all the groups except rats in the normal control. The rats in the test groups were allowed access to the fortified feed ad libitum. The animals were sacrificed; consequently, the serum, liver, and kidney were obtained for biochemical assay and histological assessment. The percentage composition of some amino acids and some proximate were higher in the fortified feed. Furthermore, Malondialdehyde (MDA) level in the liver, kidney, and serum decreased significantly (P ≤ 0.05) in rats fed with fortified feed compared to administered only Potassium bromate. Similarly, the concentration of total protein increased significantly (P ≤ 0.05) in the liver, kidney, and serum of the animals fed with fortified feed. The hematology result was normal in rats fed with fortified feed. The liver and kidney cell architecture was normal in animals fed with fortified feed. may have conferred protection and amelioration to oxidative damage by potassium bromate in rats.
林恩（洋葱）有机硫化合物和植物营养素具有药用价值。该研究评估了强化饲料中[未明确的物质，可能是洋葱相关成分]对溴酸钾引起的氧化损伤的抗氧化作用。通过用相应比例的磨碎的[未明确的物质，可能是洋葱相关成分]替代大鼠日粮的10%、20%和30%来强化商业饲料。除正常对照组的大鼠外，所有组的大鼠均经口给予溴酸钾。试验组的大鼠可随意食用强化饲料。处死动物后，获取血清、肝脏和肾脏进行生化分析和组织学评估。强化饲料中某些氨基酸和一些常规成分的百分比组成较高。此外，与仅给予溴酸钾的大鼠相比，食用强化饲料的大鼠肝脏、肾脏和血清中的丙二醛（MDA）水平显著降低（P≤0.05）。同样，食用强化饲料的动物肝脏、肾脏和血清中的总蛋白浓度显著升高（P≤0.05）。食用强化饲料的大鼠血液学结果正常。食用强化饲料的动物肝脏和肾脏细胞结构正常。[未明确的物质，可能是洋葱相关成分]可能对大鼠溴酸钾引起的氧化损伤具有保护和改善作用。
