内源性甲醛会破坏血液干细胞。
Endogenous formaldehyde destroys blood stem cells.
机构信息
The Rockefeller University.
出版信息
Blood. 2021 Apr 15;137(15):1988-1990. doi: 10.1182/blood.2020010541.
Abstract
In this issue of , Mu et al show that induced pluripotent stem cells (iPSCs) derived from patients with novel inherited bone marrow failure syndrome (IBMFS), alcohol dehydrogenase 5 (ADH5)/aldehyde dehydrogenase 2 (ALDH2) deficiency, fail to produce hematopoietic progenitors.
摘要
本期 杂志中，Mu 等人研究表明，源自新型遗传性骨髓衰竭综合征（IBMFS）、醇脱氢酶 5（ADH5）/醛脱氢酶 2（ALDH2）缺乏症患者的诱导多能干细胞（iPSC）无法生成造血祖细胞。
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Sci Adv. 2020 Dec 18;6(51). doi: 10.1126/sciadv.abd7197. Print 2020 Dec.
3
A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia.DNA 损伤激增将范可尼贫血症中的转录重编程与造血缺陷联系起来。
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