利用 H217O MRI 直接成像糖质运输。
Direct imaging of glymphatic transport using H217O MRI.
机构信息
Institute of Neuroscience and Psychology, College of Medicine, Veterinary and Life Science, University of Glasgow, Glasgow, United Kingdom.
Radiology and Medical Imaging Department, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia.
出版信息
JCI Insight. 2021 May 24;6(10):141159. doi: 10.1172/jci.insight.141159.
The recently proposed glymphatic pathway for solute transport and waste clearance from the brain has been the focus of intense debate. By exploiting an isotopically enriched MRI tracer, H217O, we directly imaged glymphatic water transport in the rat brain in vivo. Our results reveal glymphatic transport that is dramatically faster and more extensive than previously thought and unlikely to be explained by diffusion alone. Moreover, we confirm the critical role of aquaporin-4 channels in glymphatic transport.
最近提出的用于溶质转运和清除大脑废物的神经胶质淋巴途径已成为激烈争论的焦点。通过利用同位素示踪 MRI 示踪剂 H217O，我们直接在体内大鼠脑中成像了神经胶质淋巴水转运。我们的结果揭示了神经胶质转运，其速度比以前认为的要快得多，范围也更广，仅凭扩散是不可能解释的。此外，我们还证实了水通道蛋白-4 通道在神经胶质转运中的关键作用。
Zotero 插件