Department of Orthodontics, Faculty of Dentistry, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Alexandria University, Alexandria, Egypt.
Operative and Esthetic Dentistry Department, Faculty of Dentistry, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Conservative Dentistry Department, Faculty of Dentistry, Alexandria University, Alexandria, 21614, Egypt.
J Dent. 2021 Jun;109:103663. doi: 10.1016/j.jdent.2021.103663. Epub 2021 Apr 20.
45S5 Bioglass is a bioactive glass capable of releasing ions that can interact with dental hard tissues. The current study aimed at examining the effectiveness of 45S5 Bioglass in remineralizing enamel white spot lesion (WSL) as well as its effect on the bond strength of orthodontic brackets bonded to demineralized enamel.
WSLs were induced in the buccal surfaces of 135 human extracted teeth by storage in acid solution pH 4.5 for four days. The specimens were then equally divided into three groups; Demineralized group, Bioglass group (BG), and control group (intact enamel). The groups were chemically analyzed using (FTIR/ATR) Fourier-transform infrared spectroscopy/attenuated total reflectance, (XRD) X-ray diffraction, and (SEM/EDS) scanning electron microscope equipped with electron-dispersive-spectroscopy. Moreover, 10 specimens from each group were tested using Transverse Micro Radiography (TMR) technique, and 15 specimens from each group were bonded with metal orthodontic brackets and tested for shear bond strength test (SBS). The data were analyzed statistically using One way ANOVA p < 0.05.
TMR study showed that bioglass group samples recorded lesion depth of 70.19 ± 29.21 μm and Δ Z (mineral loss) 732.15 ± 210.16 vol% μm which was significantly lower than the demineralized specimens having lesion depth of 115.75 ± 19.98 μm and Δ Z (mineral loss) 3472.69 ± 738.38 vol%μm, moreover, bioglass specimens recorded 14.15 ± 2.35 Mpa which was significantly higher than demineralized specimens 6.82+1.83 Mpa but less than the control specimens 20.5 + 6.1 MPa (p < 0.05). FTIR/ATR, XRD, and SEM/EDS tests showed that bioglass paste formed a layer of brushite crystals onto the treated enamel surface.
45S5 bioglass paste may serve as an effective remineralizing agent for demineralized enamel.
45S5 生物玻璃是一种能够释放离子的生物活性玻璃，这些离子可以与牙体硬组织相互作用。本研究旨在检测 45S5 生物玻璃在再矿化釉质白斑（WSL）方面的有效性及其对黏结于脱矿釉质的正畸托槽的粘结强度的影响。
通过将标本储存在 pH 值为 4.5 的酸性溶液中四天，在 135 个人类离体牙的颊面诱导 WSL。然后，将标本等分为三组：脱矿组、生物玻璃组（BG）和对照组（完整釉质）。使用傅里叶变换红外光谱/衰减全反射（FTIR/ATR）、X 射线衍射（XRD）和配备电子色散光谱的扫描电子显微镜/能谱（SEM/EDS）对各组进行化学分析。此外，每组 10 个标本进行横向微放射照相术（TMR）检测，每组 15 个标本黏结金属正畸托槽并进行剪切粘结强度测试（SBS）。使用单因素方差分析（p < 0.05）对数据进行统计学分析。
TMR 研究显示，生物玻璃组样本的病变深度为 70.19 ± 29.21μm，ΔZ（矿物质损失）为 732.15 ± 210.16 vol%μm，显著低于脱矿组样本的病变深度 115.75 ± 19.98μm 和 ΔZ（矿物质损失）3472.69 ± 738.38 vol%μm。此外，生物玻璃组样本的粘结强度为 14.15 ± 2.35Mpa，显著高于脱矿组样本的 6.82+1.83Mpa，但低于对照组样本的 20.5+6.1Mpa（p < 0.05）。FTIR/ATR、XRD 和 SEM/EDS 测试显示，生物玻璃糊剂在处理后的釉质表面形成了一层磷酸氢钙晶体。
45S5 生物玻璃糊剂可用作脱矿釉质的有效再矿化剂。
