密螺旋体遗传学：梅毒螺旋体与五种可培养密螺旋体之间的关系
Genetics of Treponema: relationship between Treponema pallidum and five cultivable treponemes.
作者信息
Miao R, Fieldsteel A H
出版信息
J Bacteriol. 1978 Jan;133(1):101-7. doi: 10.1128/jb.133.1.101-107.1978.
Abstract
Three genetically distinct groups of treponemes have been identified by saturation reassociation assays using 125I-labeled treponemal DNAs. The three groups are (i) virulent Treponema pallidum (Nichols strain), (ii) T. phagedenis and its biotypes Reiter and Kazan 5, and (iii) T. refringens biotypes Nichols and Noguchi. There is no detectable DNA sequence homology (less than 5%) among the three groups. The groups have distinct guanine + cytosine contents: 52.4 to 53.7% for T. pallidum, 41.5% for T. refringens, and 38 to 39% for T. phagedenis.
摘要
利用125I标记的密螺旋体DNA，通过饱和重缔合分析已鉴定出三个基因不同的密螺旋体组。这三个组分别是：（i）致病性梅毒螺旋体（Nichols株），（ii）溃蚀性密螺旋体及其Reiter和Kazan 5生物型，以及（iii）屈折密螺旋体Nichols和Noguchi生物型。这三组之间没有可检测到的DNA序列同源性（低于5%）。这些组具有不同的鸟嘌呤+胞嘧啶含量：梅毒螺旋体为52.4%至53.7%，屈折密螺旋体为41.5%，溃蚀性密螺旋体为38%至39%。
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