Department of Traditional Chinese Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China.
Hospital of Xiamen University, Xiamen, Fujian, China.
Biomed Res Int. 2021 Mar 29;2021:6612477. doi: 10.1155/2021/6612477. eCollection 2021.
Myeloid-derived suppressor cells (MDSCs) have attracted attention due to their important role in inflammation. Several studies have investigated the involvement of MDSCs in chronic liver disease. However, due to the difference of MDSC phenotypes, patient types, and sample sources among the studies, the results are inconsistent and controversial. We took advantage of a large well-defined cohort of 98 (24 patients with CHB, 18 with NAFLD, 13 with HCC, 16 with PBC, and 27 with AIH) patients with liver inflammation and 12 healthy controls to investigate the expression of MDSCs, and the relationships between the expression of hepatic MDSCs and the clinical characteristics were analyzed. We found that the expression of CD11b+CD33+ MDSCs is closely related to chronic liver disease and positively correlated with clinical parameters such as ALT, AST, and globulin. Ultimately, the present study suggests that hepatic CD11b+CD33+ MDSCs are increased in HCC and AIH and positively correlate with the liver stages of hepatitis activity and liver fibrosis stage.
髓系来源的抑制细胞（MDSCs）因其在炎症中的重要作用而引起关注。多项研究已经探讨了 MDSCs 在慢性肝病中的作用。然而，由于研究中的 MDSC 表型、患者类型和样本来源存在差异，研究结果不一致且存在争议。我们利用一个由 98 名（24 名慢性乙型肝炎患者、18 名非酒精性脂肪性肝病患者、13 名肝细胞癌患者、16 名原发性胆汁性胆管炎患者和 27 名自身免疫性肝炎患者）肝脏炎症患者和 12 名健康对照组成的大型明确队列，来研究 MDSCs 的表达，并分析肝 MDSCs 的表达与临床特征之间的关系。我们发现，CD11b+CD33+MDSCs 的表达与慢性肝病密切相关，与 ALT、AST 和球蛋白等临床参数呈正相关。最终，本研究表明，肝癌和自身免疫性肝炎中肝 CD11b+CD33+MDSCs 增加，并与肝炎活动的肝脏分期和肝纤维化分期呈正相关。
