Department of Medical Statistics, University Medical Center Göttingen, Göttingen, Germany.
Clinical Development and Analytics, Novartis Pharma AG, Basel, Switzerland.
Stat Med. 2021 Jun 30;40(14):3367-3384. doi: 10.1002/sim.8967. Epub 2021 Apr 16.
The win ratio, a recently proposed measure for comparing the benefit of two treatment groups, allows ties in the data but ignores ties in the inference. In this article, we highlight some difficulties that this can lead to, and we propose to focus on the win odds instead, a modification of the win ratio which takes ties into account. We construct hypothesis tests and confidence intervals for the win odds, and we investigate their properties through simulations and in a case study. We conclude that the win odds should be preferred over the win ratio.
胜率是一种最近提出的用于比较两组治疗效果的指标,它允许数据中存在平局,但忽略了推断中的平局。在本文中,我们强调了这可能导致的一些困难,并提出转而关注胜率优势,这是对胜率的一种修改,考虑了平局。我们构建了胜率优势的假设检验和置信区间,并通过模拟和案例研究来研究它们的性质。我们的结论是,胜率优势应该优先于胜率。