Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University, Hat Yai, Songkhla 90112, Thailand.
Fitoterapia. 2019 Oct;138:104286. doi: 10.1016/j.fitote.2019.104286. Epub 2019 Aug 5.
Three new compounds including two depsidones (simplicildones J and K) and one dihydroxanthenone (globosuxanthone E) together with nine known compounds were obtained from the crude extracts of two endophytic fungi Simplicillium lanosoniveum (J.F.H. Beyma) Zare & W. Gams PSU-H168 and PSU-H261 which were isolated from the leaves of Hevea brasiliensis. The structures were elucidated by spectroscopic evidence. The absolute configuration of globosuxanthone E was established by means of experimental and calculated TDDFT ECD data. Simplicildone K exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus with equal MIC values of 128 μg/mL. Simplicildone K and globosuxanthone E displayed antifungal activity against Cryptococcus neoformans ATCC90113 with the same MIC values of 32 μg/mL. In addition, known botryohordine C and simplicildone A showed phosphodiesterase 5 inhibitory activity with the IC values of 5.69 and 9.96 μM, respectively, and were noncytotoxic toward noncancerous Vero cells.
从巴西橡胶树叶片内生真菌 Simplicillium lanosoniveum (J.F.H. Beyma) Zare & W. Gams PSU-H168 和 PSU-H261 的粗提物中分离得到三个新化合物，包括两个 depsidones（simplicildones J 和 K）和一个二羟基蒽酮（globosuxanthone E），以及九个已知化合物。结构通过光谱证据阐明。通过实验和计算的 TDDFT ECD 数据确定了 globosuxanthone E 的绝对构型。Simplicildone K 对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌表现出相同的 MIC 值为 128 μg/mL 的抗菌活性。Simplicildone K 和 globosuxanthone E 对新型隐球菌 ATCC90113 表现出相同的 MIC 值为 32 μg/mL 的抗真菌活性。此外，已知的 botryohordine C 和 simplicildone A 对磷酸二酯酶 5 具有抑制活性，IC 值分别为 5.69 和 9.96 μM，并且对非癌细胞 Vero 无细胞毒性。
