NLRP3 作为代谢异常的传感器。
NLRP3 as a sensor of metabolism gone awry.
机构信息
Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany; CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Institute of Neuropathology, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
出版信息
Curr Opin Biotechnol. 2021 Apr;68:300-309. doi: 10.1016/j.copbio.2021.03.009. Epub 2021 Apr 13.
The NLRP3 inflammasome is an important player in innate immunity and pathogenic inflammation. Numerous studies have implicated it in sensing endogenous danger signals, yet the precise mechanisms remain unknown. Here, we review the current knowledge on the organismal and cellular metabolic triggers engaging NLRP3, and the mechanisms involved in integrating the diverse signals.
NLRP3 炎性小体是先天免疫和致病炎症中的重要参与者。许多研究表明它能够感知内源性危险信号，但确切的机制仍不清楚。在这里，我们回顾了目前关于激活 NLRP3 的机体和细胞代谢触发因素的知识，以及整合各种信号的相关机制。
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