哮喘并不影响 COVID-19 的严重程度：一项荟萃分析。
Asthma does not influence the severity of COVID-19: a meta-analysis.
机构信息
Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China.
Department of Otolaryngology, The People's Hospital of Zhaoyuan City, Yantai, Shandong, China.
出版信息
J Asthma. 2022 Jun;59(6):1188-1194. doi: 10.1080/02770903.2021.1917603. Epub 2021 Apr 23.
OBJECTIVE
Previous studies have reported a correlation between coronavirus disease-2019 (COVID-19) and asthma. However, data on whether asthma constitutes a risk factor for COVID-19 and the prevalence of asthma in COVID-19 cases still remain scant. Here, we interrogated and analyzed the association between COVID-19 and asthma.
METHODS
In this study, we systematically searched PubMed, Embase, and Web of Science databases for studies published between January 1 and August 28, 2020. We included studies that reported the epidemiological and clinical features of COVID-19 and its prevalence in asthma patients. We excluded reviews, animal trials, single case reports, small case series and studies evaluating other coronavirus-related illnesses. Raw data from the studies were pooled into a meta-analysis.
RESULTS
We analyzed findings from 18 studies, including asthma patients with COVID-19. The pooled prevalence of asthma in COVID-19 cases was 0.08 (95% CI, 0.06-0.11), with an overall I of 99.07%, < 0.005. The data indicated that asthma did not increase the risk of developing severe COVID-19 (odds ratio [OR] 1.04 (95% CI, 0.75-1.46) = 0.28; I=20%). In addition, there was no significant difference in the incidence of asthma with age in COVID-19 infections [OR] 0.77(95% CI, 0.59-1.00) = 0.24; =29%).
CONCLUSION
Taken together, our data suggested that asthma is not a significant risk factor for the development of severe COVID-19.
目的
先前的研究报告了 2019 年冠状病毒病（COVID-19）与哮喘之间存在相关性。然而，关于哮喘是否构成 COVID-19 的危险因素以及 COVID-19 病例中哮喘的患病率的数据仍然很少。在这里，我们探讨并分析了 COVID-19 与哮喘之间的关联。
方法
在这项研究中，我们系统地检索了 PubMed、Embase 和 Web of Science 数据库，以获取 2020 年 1 月 1 日至 8 月 28 日期间发表的研究。我们纳入了报告 COVID-19 的流行病学和临床特征及其在哮喘患者中患病率的研究。我们排除了综述、动物试验、单一病例报告、小病例系列和评估其他冠状病毒相关疾病的研究。将研究的原始数据汇总到荟萃分析中。
结果
我们分析了包括 COVID-19 哮喘患者在内的 18 项研究的结果。COVID-19 病例中哮喘的总患病率为 0.08（95%CI，0.06-0.11），总体 I²为 99.07%，<0.005。数据表明，哮喘不会增加发展为严重 COVID-19 的风险（比值比[OR]1.04（95%CI，0.75-1.46）=0.28；I²=20%）。此外，在 COVID-19 感染中，哮喘与年龄的发生率之间没有显著差异[OR]0.77（95%CI，0.59-1.00）=0.24；I²=29%）。
结论
总的来说，我们的数据表明哮喘不是发展为严重 COVID-19 的重要危险因素。
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