Nitte (Deemed to be University), AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Department of Periodontics, Deralakatte, Mangaluru, 575018, India.
Nitte (Deemed to be University), Nitte University Centre for Science Education and Research (NUCSER), Division of Infectious Diseases, Deralakatte, Mangaluru, 575018, India.
Indian Heart J. 2021 Mar-Apr;73(2):218-220. doi: 10.1016/j.ihj.2021.01.011. Epub 2021 Jan 13.
Links between periodontitis and atherosclerosis can be predicted based on inflammatory mechanisms initiated by bacteria associated with periodontal lesions, which then influence the initiation or propagation of the atherosclerotic lesion. This study aimed to detect the presence of three periodontal pathogens, in atheromatous plaques of patients with coronary artery disease. Subgingival and atherosclerotic plaque samples were obtained from 80 patients scheduled for CABG or angioplasty. A nested PCR was done for the detection of the pathogens in the plaque samples. Porphyromonas gingivalis, Tanarella forsythia, and Treponema denticola were detected in 10%, 12.5%, and 1.3% of the atherosclerotic plaque samples respectively. It was also observed that patients whose atherosclerotic plaques tested positive for one or more of the pathogens had chronic periodontitis.
牙周炎和动脉粥样硬化之间的联系可以基于与牙周病损相关的细菌引发的炎症机制来预测，这些机制随后影响动脉粥样硬化病变的起始或发展。本研究旨在检测冠心病患者粥样斑块中三种牙周病原体的存在情况。从 80 名计划接受 CABG 或血管成形术的患者中获取龈下和动脉粥样硬化斑块样本。对斑块样本进行巢式 PCR 以检测病原体。分别在 10%、12.5%和 1.3%的动脉粥样硬化斑块样本中检测到牙龈卟啉单胞菌、福赛斯坦纳菌和牙髓密螺旋体。还观察到，动脉粥样硬化斑块检测到一种或多种病原体呈阳性的患者患有慢性牙周炎。
