Department of Kinesiology, College of Nursing and Health Innovation, University of Texas at Arlington, Arlington, TX 76010, USA.
Neurosci Lett. 2021 May 29;754:135899. doi: 10.1016/j.neulet.2021.135899. Epub 2021 Apr 15.
The volitional movement of skeletal is controlled by the motor neuron at the site of neuromuscular junction (NMJ) where the retrograde signals are also passed back from muscle to the motor neuron. As the normal function of muscle largely depends on mitochondria that determine the fate of a skeletal muscle myofiber, there must exist a fine-controlled functional coupling between NMJ and mitochondria in myofibers. This mini-review discusses recent publications that reveal how spatiotemporal profiles of intracellular free Ca could couple mitochondrial function with the activity of NMJ in skeletal muscle myofibers.
骨骼的随意运动受运动神经元控制，运动神经元位于神经肌肉接头（NMJ）处，逆行信号也从肌肉传递回运动神经元。由于肌肉的正常功能在很大程度上取决于决定骨骼肌肌纤维命运的线粒体，因此 NMJ 和肌纤维中线粒体之间必须存在精细控制的功能偶联。这篇小综述讨论了最近的出版物，揭示了细胞内游离 Ca 的时空分布如何将线粒体功能与骨骼肌肌纤维中 NMJ 的活性偶联起来。
