Division of Bone Marrow Transplantation, Brazilian Cancer Control Institute, São Paulo, SP, Brazil; Graduate Program in Implantology, University of Santo Amaro, School of Dentistry, São Paulo, SP, Brazil.
Division of Bone Marrow Transplantation, Brazilian Cancer Control Institute, São Paulo, SP, Brazil.
Photodiagnosis Photodyn Ther. 2021 Jun;34:102296. doi: 10.1016/j.pdpdt.2021.102296. Epub 2021 Apr 15.
In hematopoietic cell transplants (HCT) patients, opportunistic fungal infections - especially candidiasis - are typical and, due to the immunosuppressed condition, severe and fatal clinical conditions may occur. Many antifungal agents are used for treating candidiasis; however, there are non-responsive, drug-resistant cases in which alternative antimicrobial therapies are strongly needed. The present study aimed to report a clinical case in which antimicrobial photodynamic therapy (aPDT) was used for extensive oral pseudomembranous candidiasis not responsive to micafungin in a patient undergoing HCT. Thus, 0.01 % methylene blue solution was applied for 3 min onto the infected area, followed by 660-nm laser irradiation. Within 72 h, there was neither a symptom nor a sign of the fungal infection. According to the current case report, aPDT seems to be highly effective for HCT patients presenting oral candidiasis not responsive to micafungin; however, further studies are necessary.
在造血细胞移植（HCT）患者中，机会性真菌感染 - 特别是念珠菌感染 - 很常见，由于免疫抑制状态，可能会出现严重和致命的临床情况。许多抗真菌药物可用于治疗念珠菌病；然而，存在无反应性、耐药性病例，强烈需要替代抗菌治疗。本研究旨在报告一例临床病例，在 HCT 患者中，对于对米卡芬净无反应的广泛口腔假膜性念珠菌病，使用了光动力疗法（aPDT）。因此，将 0.01%亚甲蓝溶液应用于感染区域 3 分钟，然后用 660nm 激光照射。在 72 小时内，没有任何真菌感染的症状或体征。根据目前的病例报告，aPDT 似乎对米卡芬净无反应的 HCT 患者的口腔念珠菌病非常有效；然而，需要进一步的研究。
