Department of Dentistry, Laboratório de Pesquisa em Saúde, Hospital Universitário Clemente Faria, Universidade Estadual de Montes Claros (Unimontes), 562 Av. Cula Mangabeira Santo Expedito, Montes Claros, Minas Gerais 39401-001, Brazil.
Dilson Godinho Hospital, Montes Claros, Minas Gerais, Brazil.
Photodiagnosis Photodyn Ther. 2022 Sep;39:102983. doi: 10.1016/j.pdpdt.2022.102983. Epub 2022 Jun 27.
Purpose This study aimed to compare the efficacy of Antimicrobial Photodynamic Therapy (aPDT) with 300 µmol/L of methylene blue and 8 µmol/L of curcumin on oral candidiasis patients with HNSCC undergoing treatment. Methods A two-arm, single-blind clinical trial was performed. Following verification for eligibility (n = 447), 108 patients were included in the study. The study consisted of a group that received aPDT with methylene blue (n = 57) and another that received aPDT with curcumin (n = 51). The patients rinsed their mouths with an aqueous solution of 300 µmol/L of methylene blue and 8 µmol/L of curcumin in four sessions, and then the lesion was scraped for the subsequent RT-qPCR. The primary outcome was that no cure was presented for oral candidiasis after treatment. The secondary result was reducing the number of sites affected by oral candidiasis. Results There was no difference in treatment failure evaluated by the necessity of drug prescription or Candida sp DNA quantification. However, clinically the methylene blue protocol reduced the number of infected anatomical sites compared to the curcumin protocol. Conclusion Methylene blue aPDT reduced the number of infected anatomical sites compared to curcumin.
本研究旨在比较 300µmol/L 亚甲蓝和 8µmol/L 姜黄素的光动力疗法（aPDT）对接受治疗的头颈部鳞状细胞癌伴口腔念珠菌病患者的疗效。
采用双臂、单盲临床试验。在验证合格（n=447）后，纳入 108 名患者。该研究包括接受亚甲蓝 aPDT 的组（n=57）和接受姜黄素 aPDT 的组（n=51）。患者在四个疗程中用 300µmol/L 亚甲蓝和 8µmol/L 姜黄素的水溶液漱口，然后刮取病变组织进行随后的 RT-qPCR。主要结局是治疗后口腔念珠菌病未治愈。次要结果是减少口腔念珠菌病受累部位的数量。
无论是通过药物处方的必要性还是念珠菌 sp DNA 定量评估，治疗失败方面没有差异。然而，与姜黄素方案相比，亚甲蓝方案在临床上减少了感染解剖部位的数量。
与姜黄素相比，亚甲蓝 aPDT 减少了感染解剖部位的数量。
