Department of Psychology and Neuroscience, University of Colorado, 345 UCB, Boulder, CO, 80309-0345, USA.
Department of Psychology and Neuroscience, University of Colorado, 345 UCB, Boulder, CO, 80309-0345, USA.
Drug Alcohol Depend. 2021 Jun 1;223:108718. doi: 10.1016/j.drugalcdep.2021.108718. Epub 2021 Apr 20.
An innovative naturalistic at-home administration procedure was used to investigate sex differences in subjective drug effects and verbal memory errors after ad libitum use of high potency state legal market Δ9-tetrahydrocannabinol (THC) concentrate.
Regular concentrate users were randomly assigned to ad libitum administration of one of two cannabis concentrate products (70 % or 90 % THC) that they purchased from a dispensary. 65 participants (N = 34 men, N = 31 women) were assessed in a mobile pharmacology lab before, immediately after, and 1 -h after ad libitum concentrate use. Plasma cannabinoids (THC, 11-OH-THC, CBD), subjective drug effects, and verbal memory errors were assessed at all three time points.
Although men and women exhibited similar plasma 11-OH-THC levels across time (p = .10), sex differences were found in plasma THC and CBD after legal market concentrate use, with men displaying significantly higher levels of plasma THC and CBD immediately after cannabis concentrate use (plasma THC [ng/mL]: M = 489.88, M = 135.08, p < .001; plasma CBD [ng/mL]: M = 1.14, M = 0.53, p = .04). Despite this, sex differences in subjective effects and verbal memory errors did not emerge, although women reported a steeper decrease in drug liking after use (p = .04).
These data provide the first look at sex differences after acute naturalistic cannabis concentrate use, and suggest much higher THC exposure in men versus women, but similar acute drug and impairment effects across the sexes. Further studies are needed to determine the mechanisms (e.g. tolerance, cannabinoid metabolism, smoking topography) behind these findings.
采用一种创新的自然家庭给药程序，研究了在合法的高浓度市场 Δ9-四氢大麻酚（THC）浓缩物随意使用后，主观药物效应和言语记忆错误的性别差异。
定期使用浓缩物的参与者被随机分配到随意使用他们从药房购买的两种大麻浓缩物产品（70%或 90% THC）之一。65 名参与者（N=34 名男性，N=31 名女性）在移动药理学实验室中进行评估，在随意使用浓缩物之前、之后立即以及之后 1 小时进行评估。在所有三个时间点都评估了血浆大麻素（THC、11-羟基-THC、CBD）、主观药物效应和言语记忆错误。
尽管男性和女性在整个时间内表现出相似的血浆 11-羟基-THC 水平（p=.10），但在合法市场浓缩物使用后，男性和女性在血浆 THC 和 CBD 方面存在性别差异，男性在使用大麻浓缩物后立即显示出更高的血浆 THC 和 CBD 水平（血浆 THC [ng/mL]：M=489.88，M=135.08，p<.001；血浆 CBD [ng/mL]：M=1.14，M=0.53，p=.04）。尽管如此，在主观效应和言语记忆错误方面并未出现性别差异，尽管女性在使用后报告药物喜好程度下降更明显（p=.04）。
这些数据首次提供了急性自然主义大麻浓缩物使用后性别差异的观察结果，表明男性比女性的 THC 暴露更高，但男女之间的急性药物和损伤效应相似。需要进一步的研究来确定这些发现背后的机制（例如，耐受性、大麻素代谢、吸烟模式）。
