Sarfaraz Sana, Ikram Rahela, Osama Muhammad, Anser Humera
Department of Pharmacology, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan.
Department of Pharmacology, Faculty of Pharmacy, Jinnah Sindh Medical University, Karachi, Pakistan.
Pak J Pharm Sci. 2020 Nov;33(6):2505-2510.
Infertility has recently been a common issue for which multiple medicinal as well as surgical treatments are available. Beta vulgaris commonly referred to as garden beet is one of the most utilized vegetable especially in salad dressings. The Present study was conducted to evaluate the effect of lyophilized beet root on fertility and reproductive hormones. The study was carried out in January 2017 on two different animal models. For fertility purpose albino mice of both genders weighing 20-25gm were divided into 5 pairs for each group, First group was control given distilled water, next was treated I being given beetroot 500mg/kg and last one was given 1000mg/kg beetroot. Similarly 5 pairs were made of buck and doe's weighing 1.75gm-2.5gm and labelled as Control, Treated I and Treated II and were administered distilled water, 500mg/kg and 1000mg/kg beetroot respectively. The pups were again mated after they grew up and in this way F1 generation was also observed. The kits were observed for presence of anomaly. The estrogen, progesterone and testosterone levels were evaluated at baseline, during pregnancy and post pregnancy in rabbit model. Improved fertility with no anomalies in the pups and kits were observed. The reproductive hormones were also highly significantly increased (p<0.001) as compared to baseline values. The study suggests that beetroot would be very beneficial in improving fertility and maintaining hormonal level during fertility hence it would prove to be very beneficial in maintaining pregnancy as well as treating infertility.
不孕症近来已成为一个常见问题，针对此有多种药物及手术治疗方法。甜菜（Beta vulgaris）通常被称为园甜菜，是最常被食用的蔬菜之一，尤其用于制作沙拉酱。本研究旨在评估冻干甜菜根对生育能力及生殖激素的影响。该研究于2017年1月在两种不同动物模型上进行。为研究生育能力，将体重20 - 25克的雌雄白化小鼠每组分为5对，第一组为对照组，给予蒸馏水，第二组为处理I组，给予500毫克/千克甜菜根，最后一组为处理II组，给予1000毫克/千克甜菜根。同样，将体重1.75 - 2.5克的雄兔和雌兔分为5对，标记为对照组、处理I组和处理II组，分别给予蒸馏水、500毫克/千克和1000毫克/千克甜菜根。幼崽长大后再次交配，以此方式观察F1代。观察幼崽是否存在异常。在兔模型中，于基线期、孕期及产后评估雌激素、孕酮和睾酮水平。观察到生育能力提高，幼崽和幼兔无异常。与基线值相比，生殖激素水平也显著升高（p<0.001）。该研究表明，甜菜根在提高生育能力及维持生育期间的激素水平方面非常有益，因此在维持妊娠及治疗不孕症方面也将被证明非常有益。
