Department of Pharmacology, Faculty of Pharmacy & Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.
Faculty of Pharmacy, Salim Habib University, Karachi, Pakistan.
Pak J Pharm Sci. 2021 Jul;34(4):1315-1322.
A diet comprising of nutrients that would control hypertension as well as hyperlipidemia would be very beneficial over all. This study aimed to assess the effect of lyophilized beet root powder at different doses on lipid profile and hyperlipidemia model. Albino rabbits weighing 1500-2000gms were taken for both studies. Beetroot powder was administered to animals at 500mg/kg and 1000mg/kg doses and after two month dosing the blood samples were withdrawn and lipid profile was assessed. Next a model of hyperlipidemia was created comprising of albino rabbits that were divided into five groups each containing n=6. Group I was considered as control, Group II was marked as Negative control, Group III was taken as standard, whereas Group IV and V were considered as treated and given different doses of beetroot. Blood samples were drawn at baseline, 45th day and at day 60th of study. Highly significant decrease in lipid profile (Cholesterol, LDL and TGS) and significant increase in HDL was observed by both doses after one month. HDL was increased more at 1000mg/kg dose. The presence of flavonoids and saponins in beetroot is responsible for hypolipidemic effect. From our research we came to the conclusion that beetroot powder reduced the lipid profile and could be beneficial in treatment of cardiovascular disease due to atherosclerosis and obesity.
一种既能控制高血压又能控制高血脂的营养饮食将是非常有益的。本研究旨在评估不同剂量冻干甜菜根粉对血脂谱和高血脂模型的影响。本研究分别选用了体重为 1500-2000g 的白化兔。给动物喂食 500mg/kg 和 1000mg/kg 的剂量的甜菜根粉，两个月后取血样，评估血脂谱。接下来，创建了一个高血脂模型，包括将白化兔分为五组，每组 n=6。第 I 组被认为是对照组，第 II 组被标记为阴性对照组，第 III 组被标记为标准组，而第 IV 组和第 V 组被认为是治疗组，并给予不同剂量的甜菜根。在研究的第 0 天、第 45 天和第 60 天抽取血样。经过一个月的治疗，两种剂量均能显著降低血脂谱（胆固醇、LDL 和 TGS），显著升高 HDL。在 1000mg/kg 剂量下，HDL 升高更为明显。甜菜根中类黄酮和皂苷的存在是其具有降血脂作用的原因。从我们的研究中得出结论，甜菜根粉可以降低血脂谱，可能有助于治疗由于动脉粥样硬化和肥胖引起的心血管疾病。
