Welschmeyer Alexandra, Berke Gerald S
Georgetown University School of Medicine Washington District of Columbia USA.
Department of Head and Neck Surgery Ronald Reagan UCLA Medical Center Los Angeles California USA.
Laryngoscope Investig Otolaryngol. 2021 Jan 28;6(2):226-233. doi: 10.1002/lio2.521. eCollection 2021 Apr.
To identify studies evaluating the epidemiology of recurrent respiratory papillomatosis (RRP), including patient demographics, human papillomavirus (HPV) immunology, clinical course, surgical and medical treatments, and psychosocial factors.
A systematic literature search through PubMed was performed to identify studies evaluating the epidemiological factors associated with RRP. All studies were screened through a priori selection criteria using the titles and abstracts.
A total of 208 studies were identified, of which 54 met eligibility criteria and were included in the review.
RRP is a rare disease most commonly caused by HPV 6 and 11. It is characterized by recurring benign papillomatous lesions in the respiratory tract, particularly the larynx. Existing evidence about disease risk factors is limited but includes both maternal HPV infection and patient smoking and sexual behaviors. Disease management involves a combination of routine surgical and medical treatment. Surgical techniques include CO-laser, sharp dissection, coblation, microdebridement, and photoangiolytic laser. Medical treatments which have been found to facilitate disease control off-label include interferon-alpha (IFN-α), indole-3-carbinol, acyclovir, bevacizumab, retinoids, and the Gardasil and mumps vaccines. Many patients suffer from additional psychosocial challenges related to their diagnosis. Current disease knowledge remains limited, and more robust controlled trials about risk factors, medical therapies, and surgical options are needed.
确定评估复发性呼吸道乳头状瘤病（RRP）流行病学的研究，包括患者人口统计学、人乳头瘤病毒（HPV）免疫学、临床病程、手术和药物治疗以及社会心理因素。
通过PubMed进行系统的文献检索，以确定评估与RRP相关的流行病学因素的研究。所有研究均通过使用标题和摘要的先验选择标准进行筛选。
共识别出208项研究，其中54项符合纳入标准并被纳入综述。
RRP是一种罕见疾病，最常见由HPV 6和11引起。其特征是呼吸道尤其是喉部反复出现良性乳头状瘤病变。关于疾病危险因素的现有证据有限，但包括母亲HPV感染以及患者吸烟和性行为。疾病管理涉及常规手术和药物治疗的联合。手术技术包括CO2激光、锐性剥离、低温等离子消融、显微清创和光动力激光。已发现可在标签外促进疾病控制的药物治疗包括α干扰素（IFN-α）、吲哚-3-甲醇、阿昔洛韦、贝伐单抗、维甲酸以及加德西疫苗和腮腺炎疫苗。许多患者因诊断而面临额外的社会心理挑战。目前对该疾病的了解仍然有限，需要更多关于危险因素、药物治疗和手术选择的有力对照试验。
5级。
