与严重程度相关的青少年发病型喉乳头状瘤的组织病理学特征。

Histopathological features of juvenile-onset laryngeal papillomatosis related to severity.

机构信息

Department of Bioscience and Oral Diagnosis, Institute of Science and Technology, São Paulo State University - Unesp, São José dos Campos, Brazil.

Department of Pathology, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil.

出版信息

Head Neck. 2019 May;41(5):1412-1417. doi: 10.1002/hed.25602. Epub 2019 Jan 8.

DOI:10.1002/hed.25602

PMID:30623508

Abstract

BACKGROUND

Laryngeal papillomatosis (LP) is a disease that presents in both juvenile (JLP) and adult patients (ALP). This study correlated papillomatosis characteristics with the Derkay score.

METHODS

Retrospective data and biopsies of 36 patients with JLP and 56 with ALP were collected and separated into groups according to their scores.

RESULTS

The mean of the Derkay score, in the JLP group was 10.97 and in Group ALP was 8.26. The JLP group presented a more aggressive result than in the adult group (P = .02). In the JLP group, the respiratory difficulty (P = .01) and tracheostomy were correlated to a higher Derkay score (P < .05). Microscopically, the JLP samples presented a higher incidence of atypical mitosis and mitosis above the basal cells layer of the epithelium (P < .05) and these characteristics were correlated with a higher Derkay index (P = .03).

CONCLUSION

Findings suggest that ALP and JLP can present different clinical courses and histopathological features. There was a higher degree of LP severity in JLP.

摘要

背景

喉乳头状瘤病（LP）是一种在青少年（JLP）和成人（ALP）患者中均会出现的疾病。本研究将乳头状瘤病的特征与 Derkay 评分相关联。

方法

收集了 36 例 JLP 和 56 例 ALP 患者的回顾性数据和活检，并根据他们的评分将其分成不同的组。

结果

JLP 组的 Derkay 评分平均值为 10.97，ALP 组为 8.26。与成人组相比，JLP 组的结果更具侵袭性（P = 0.02）。在 JLP 组中，呼吸困难（P = 0.01）和气管切开术与更高的 Derkay 评分相关（P < 0.05）。镜下，JLP 样本中不典型有丝分裂和上皮基底细胞层以上有丝分裂的发生率更高（P < 0.05），这些特征与更高的 Derkay 指数相关（P = 0.03）。