Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China.
Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang, China.
J Sleep Res. 2021 Oct;30(5):e13366. doi: 10.1111/jsr.13366. Epub 2021 Apr 18.
Daytime napping is common in many regions around the world and has been an important part of people's daily life. Daytime napping has attracted increasing attention in recent years. Thus, we conducted a meta-analysis to evaluate the relationship between daytime napping and stroke, and help reduce the risk of stroke by improving living habits. The Embase, PubMed, Web of Science and PsycINFO databases were searched for cohort studies published before October 2020 and eight eligible studies with 524,408 participants and 5,875 stroke cases were included in the final analysis. The pooled relative risk (RR) of stroke was 1.47 (95% confidence interval [CI]: 1.24-1.74; p < .001) with significant heterogeneity (I = 58%, p for heterogeneity = 0.02). However, the heterogeneity decreased when the study in which adjusting for sleep duration and stratifying the results based on sleep duration was not performed was excluded (RR: 1.38; 95% CI: 1.19-1.60, I = 44%, p for heterogeneity = 0.10). In dose-response analysis, the linear trend indicated that for every 10-min increase in daytime napping, the risk of stroke increased by 3%. Further well-designed large studies are needed to explore the effects of daytime napping on stroke and the underlying biological mechanisms.
白天小睡在世界许多地区很常见，是人们日常生活的重要组成部分。近年来，白天小睡引起了越来越多的关注。因此，我们进行了一项荟萃分析，以评估白天小睡与中风之间的关系，并通过改善生活习惯来降低中风的风险。我们检索了 Embase、PubMed、Web of Science 和 PsycINFO 数据库，纳入了截至 2020 年 10 月前发表的队列研究，最终分析共纳入了 8 项符合条件的研究，涉及 524408 名参与者和 5875 例中风病例。中风的合并相对风险（RR）为 1.47（95%置信区间[CI]：1.24-1.74；p<0.001），存在显著的异质性（I²=58%，p 异质性=0.02）。然而，当排除未调整睡眠时间和基于睡眠时间分层结果的研究时，异质性降低（RR：1.38；95%CI：1.19-1.60，I²=44%，p 异质性=0.10）。在剂量反应分析中，线性趋势表明，白天小睡每增加 10 分钟，中风风险增加 3%。需要进一步进行设计良好的大型研究，以探讨白天小睡对中风的影响及其潜在的生物学机制。
