Lorenz Kent Arnold, Yeshurun Shlomo, Aziz Richard, Ortiz-Delatorre Julissa, Bagley James Robert, Mor Merav, Kern Marialice
Department of Kinesiology, San Francisco State University, San Francisco, CA, United States.
Metaflow Ltd, Tel Aviv, Israel.
Interact J Med Res. 2021 May 17;10(2):e25371. doi: 10.2196/25371.
Metabolic carts measure the carbon dioxide (CO) produced and oxygen consumed by an individual when breathing to assess metabolic fuel usage (carbohydrates versus fats). However, these systems are expensive, time-consuming, and only available in health care laboratory settings. A small handheld device capable of determining metabolic fuel usage via CO from exhaled air has been developed.
The aim of this study is to evaluate the validity of a novel handheld device (Lumen) for measuring metabolic fuel utilization in healthy young adults.
Metabolic fuel usage was assessed in healthy participants (n=33; mean age 23.1 years, SD 3.9 years) via respiratory exchange ratio (RER) values obtained from a metabolic cart as well as % CO from the Lumen device. Measurements were performed at rest in two conditions: fasting, and after consuming 150 grams of glucose, in order to determine changes in metabolic fuel usage. Reduced major axis regression and simple linear regression were performed to test for agreement between RER and Lumen % CO.
Both RER and Lumen % CO significantly increased after glucose intake (P<.001 for both) compared with fasting conditions, by 0.089 and 0.28, respectively. Regression analyses revealed an agreement between the two measurements (F=18.54; P<.001).
This study shows the validity of Lumen for detecting changes in metabolic fuel utilization in a comparable manner with a laboratory standard metabolic cart, providing the ability for real-time metabolic information for users under any circumstances.
代谢车可测量个体呼吸时产生的二氧化碳（CO）和消耗的氧气，以评估代谢燃料的使用情况（碳水化合物与脂肪）。然而，这些系统价格昂贵、耗时，且仅在医疗保健实验室环境中可用。现已开发出一种小型手持设备，能够通过呼出气体中的CO来确定代谢燃料的使用情况。
本研究旨在评估一种新型手持设备（Lumen）在健康年轻成年人中测量代谢燃料利用情况的有效性。
通过代谢车获得的呼吸交换率（RER）值以及Lumen设备测得的CO百分比，对健康参与者（n = 33；平均年龄23.1岁，标准差3.9岁）的代谢燃料使用情况进行评估。在两种情况下进行静息测量：空腹，以及摄入150克葡萄糖后，以确定代谢燃料使用情况的变化。进行简约主轴回归和简单线性回归，以检验RER与Lumen CO百分比之间的一致性。
与空腹状态相比，摄入葡萄糖后RER和Lumen CO百分比均显著增加（两者P <.001），分别增加了0.089和0.28。回归分析显示两种测量结果具有一致性（F = 18.54；P <.001）。
本研究表明Lumen能够以与实验室标准代谢车类似的方式检测代谢燃料利用情况的变化，可为用户在任何情况下提供实时代谢信息。
