重复序列的Alu家族中的一个基本分类。
A fundamental division in the Alu family of repeated sequences.
作者信息
Jurka J, Smith T
机构信息
Bionet, Mountain View, CA 94040.
出版信息
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4775-8. doi: 10.1073/pnas.85.13.4775.
Abstract
The Alu family of repeated sequences from the human genome contains two distinct subfamilies. This division is based on different base preferences in a number of diagnostic sequence positions. One subfamily of the sequences, referred to as the Alu-J subfamily, is very similar to 7SL DNA in these positions. The other subfamily, Alu-S, can be divided further into well-defined branches of sequences. These findings revise the previous picture of the Alu family and expose their complex evolutionary dynamics. They reveal sequence variations of potential importance for the proliferation of Alu repeats and relate them to their structural features. In addition, they open the possibility of using different types of Alu sequences as natural markers for studying genetic rearrangements in the genome.
摘要
人类基因组中的Alu重复序列家族包含两个不同的亚家族。这种划分是基于在一些诊断性序列位置上不同的碱基偏好。其中一个序列亚家族，称为Alu-J亚家族，在这些位置上与7SL DNA非常相似。另一个亚家族Alu-S可以进一步分为明确的序列分支。这些发现修正了之前关于Alu家族的认识，并揭示了它们复杂的进化动态。它们揭示了对于Alu重复序列增殖具有潜在重要性的序列变异，并将其与结构特征联系起来。此外，它们开启了使用不同类型的Alu序列作为天然标记来研究基因组中基因重排的可能性。
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本文引用的文献
1
Identification of common molecular subsequences.常见分子子序列的鉴定
J Mol Biol. 1981 Mar 25;147(1):195-7. doi: 10.1016/0022-2836(81)90087-5.
2
A monkey Alu sequence is flanked by 13-base pair direct repeats by an interrupted alpha-satellite DNA sequence.一个猴Alu序列由13个碱基对的同向重复序列侧翼包围，并被一个中断的α卫星DNA序列隔开。
Proc Natl Acad Sci U S A. 1982 Mar;79(5):1497-500. doi: 10.1073/pnas.79.5.1497.
3
Alu sequences are processed 7SL RNA genes.Alu序列是经过加工的7SL RNA基因。
Nature. 1984;312(5990):171-2. doi: 10.1038/312171a0.
4
Structure and evolution of the 7SL RNA component of the signal recognition particle.信号识别颗粒的7SL RNA组分的结构与进化
EMBO J. 1984 Oct;3(10):2325-32. doi: 10.1002/j.1460-2075.1984.tb02134.x.
5
Revision of consensus sequence of human Alu repeats--a review.人类Alu重复序列共有序列的修订——综述
Gene. 1987;53(1):1-10. doi: 10.1016/0378-1119(87)90087-4.
6
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Proc Natl Acad Sci U S A. 1988 Jul;85(13):4770-4. doi: 10.1073/pnas.85.13.4770.
7
Existence of at least three distinct Alu subfamilies.至少存在三个不同的Alu亚家族。
J Mol Evol. 1987;26(3):180-6. doi: 10.1007/BF02099850.
8
Clustering and subfamily relationships of the Alu family in the human genome.人类基因组中Alu家族的聚类和亚家族关系。
Mol Biol Evol. 1987 Jan;4(1):19-29. doi: 10.1093/oxfordjournals.molbev.a040422.
9
The multiple origins of human Alu sequences.人类Alu序列的多重起源
J Mol Evol. 1986;23(3):189-99. doi: 10.1007/BF02115575.
10
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