人类Alu重复序列的来源与进化
Sources and evolution of human Alu repeated sequences.
作者信息
Britten R J, Baron W F, Stout D B, Davidson E H
机构信息
Division of Biology, California Institute of Technology, Pasadena 91125.
出版信息
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4770-4. doi: 10.1073/pnas.85.13.4770.
Abstract
Alu repeated sequences arising in DNA of the human lineage during about the last 30 million years are closely similar to a modern consensus. Alu repeats arising at earlier times share correlated blocks of differences from the current consensus at diagnostic positions in the sequence. Using these 26 positions, we can recognize four subfamilies and the older ones are each successively closer to the 7SL sequence. It appears that there has existed a series of conserved genes that are the primary sources of the Alu repeat family, presumably through retroposition. These genes have probably replaced each other in overlapping relays during the evolution of primates.
摘要
在过去约三千万年中出现在人类谱系DNA中的Alu重复序列与现代共有序列非常相似。早期出现的Alu重复序列在序列的诊断位置上与当前共有序列存在相关的差异块。利用这26个位置，我们可以识别出四个亚家族，并且较古老的亚家族与7SL序列的相似度依次递增。似乎存在一系列保守基因，它们可能是Alu重复序列家族的主要来源，推测是通过逆转座作用。在灵长类动物的进化过程中，这些基因可能在重叠的接力过程中相互取代。
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