Scientific Institute for Research, Hospitalization and Health Care (IRCCS) Santa Lucia Foundation, Rome, Italy.
Clin Rehabil. 2021 Oct;35(10):1399-1412. doi: 10.1177/02692155211010372. Epub 2021 Apr 20.
To evaluate the effects of dual-task training on static and dynamic balance in patients with multiple sclerosis.
PubMed/MEDLINE, EMBASE, Scopus, and PEDro databases were searched from inception to March 1, 2021.
This study was conducted in agreement with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two reviewers assessed studies for inclusion and extracted data. We used the Physiotherapy Evidence Database scale to evaluate the methodological quality and the risk-of-bias. Randomized clinical trial data were pooled for the meta-analysis. The effect sizes and 95% confidence interval (CI) were calculated by random-effect models. Egger regression and Begg-Mazumdar rank correlation test were used for publication bias.
A total of 13 studies involving 584 patients (42.3 ± 9 years mean ± SD; 377 females) met the inclusion criteria for the systematic review, while nine were included in the meta-analysis. People who received dual-task training interventions showed significant improvements in the Timed Up & Go test 0.44 [(95% CI = 0.22; 0.65), -value<0.001], and in the Berg Balance scale 0.46 [(95% CI = 0.07; 0.85), -value = 0.02]. Low and moderate heterogeneity between the studies was found for the Timed Up & Go test and the Berg Balance scale, respectively.
The findings from the current meta-analysis support dual-task training as a beneficial therapy for improving dynamic balance and functional mobility in patients with multiple sclerosis. The limited number of studies that investigated static balance performance after dual-task training do not currently allow us to draw a conclusion about any possible improvements in this ability.
评估双重任务训练对多发性硬化症患者静态和动态平衡的影响。
从建库到 2021 年 3 月 1 日，在 PubMed/MEDLINE、EMBASE、Scopus 和 PEDro 数据库中进行了检索。
本研究符合系统评价和荟萃分析的首选报告项目（PRISMA）指南。两位审查员评估了纳入的研究并提取了数据。我们使用物理治疗证据数据库量表来评估方法学质量和偏倚风险。随机临床试验数据进行荟萃分析。使用随机效应模型计算效应大小和 95%置信区间（CI）。Egger 回归和 Begg-Mazumdar 等级相关检验用于检测发表偏倚。
共有 13 项研究（共 584 名患者，42.3±9 岁，平均±标准差；377 名女性）符合系统综述的纳入标准，其中 9 项研究纳入荟萃分析。接受双重任务训练干预的患者在计时起立行走测试中显著改善 0.44（95%CI=0.22；0.65），Berg 平衡量表中显著改善 0.46（95%CI=0.07；0.85），-值均<0.001。计时起立行走测试和 Berg 平衡量表的研究间存在低至中度异质性。
目前荟萃分析的结果支持双重任务训练作为一种有益的治疗方法，可改善多发性硬化症患者的动态平衡和功能性移动能力。目前，关于双重任务训练后静态平衡表现的研究数量有限，我们无法得出任何关于这种能力可能改善的结论。
