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高血压患者动脉粥样硬化性心血管疾病危险因素的种族/民族差异:来自 143 个初级保健诊所的分析。

Race/Ethnic Differences in Atherosclerotic Cardiovascular Disease Risk Factors Among Patients With Hypertension: Analysis From 143 Primary Care Clinics.

机构信息

Advocate Aurora Research Institute, Advocate Aurora Health, Downers Grove, Illinois, USA.

Center for Healthcare Delivery Sciences, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.

出版信息

Am J Hypertens. 2021 Sep 22;34(9):948-955. doi: 10.1093/ajh/hpab053.

Abstract

BACKGROUND

While it is known that sex and race/ethnic disparities persist for atherosclerotic cardiovascular disease (ASCVD), disparities in risk factor control have not been well-described in primary care where ASCVD can be prevented.

METHODS

Adult patients with a hypertension diagnosis without ASCVD were included in this analysis of electronic health records from a large US healthcare system from 2018. Patients were categorized based on risk factor control defined as blood pressure (BP) <130/80 mm Hg; statin prescription among patients with indications, HbA1c of <7%, and not smoking. Multivariable Poisson regressions were developed to explore associations with race/ethnicity. Results are presented as relative risk (RR), 95% confidence intervals (CIs).

RESULTS

Among 5,227 patients, 55.8% women and 60.0% men had uncontrolled BP, 47.3% women and 46.4% men with statin therapy indication did not have a prescription, 34.9% women and 40.9% men had uncontrolled HbA1c values, and 9.3% women and 13.7% men were smokers. African Americans were more likely to have uncontrolled BP (women: RR 1.18, 95% CI 1.07-1.30; men: RR 1.20, 95% CI 1.05-1.34) and more likely to lack a statin prescription (women: RR 1.23, 95% CI 1.05-1.45; men: RR 1.25, 95% CI 1.03-1.51) compared to Caucasians. Differences in HbA1c control were not statistically significant among Hispanic/Latino compared to Caucasians (women: RR 1.28, 95% CI 0.86-1.90; men: RR 1.20, 95% CI 0.72-1.97).

CONCLUSIONS

Disparities in controlling ASCVD risk factors in primary care persist and were not fully explained by demographic or clinical characteristics. Monitoring changes in disparities is important to ensure equity as interventions to prevent ASCVD in primary care are developed and implemented.

摘要

背景

尽管已知在可预防动脉粥样硬化性心血管疾病 (ASCVD) 的初级保健中,性别和种族/族裔差异仍然存在,但在危险因素控制方面的差异尚未得到很好描述。

方法

本研究分析了来自美国大型医疗保健系统的电子健康记录中 2018 年患有高血压但无 ASCVD 的成年患者数据。患者根据危险因素控制情况进行分类,定义为血压(BP)<130/80mmHg;有他汀类药物治疗指征的患者开出处方,糖化血红蛋白(HbA1c)<7%,且不吸烟。采用多变量泊松回归探讨与种族/族裔的关系。结果以相对风险(RR)和 95%置信区间(CI)表示。

结果

在 5227 名患者中,55.8%的女性和 60.0%的男性血压控制不佳,47.3%的女性和 46.4%的男性有他汀类药物治疗指征但未开处方,34.9%的女性和 40.9%的男性 HbA1c 值控制不佳,9.3%的女性和 13.7%的男性吸烟。非裔美国人更有可能血压控制不佳(女性:RR 1.18,95%CI 1.07-1.30;男性:RR 1.20,95%CI 1.05-1.34),且更有可能未开他汀类药物处方(女性:RR 1.23,95%CI 1.05-1.45;男性:RR 1.25,95%CI 1.03-1.51),而非白人。与白人相比,西班牙裔/拉丁裔在控制 HbA1c 方面的差异无统计学意义(女性:RR 1.28,95%CI 0.86-1.90;男性:RR 1.20,95%CI 0.72-1.97)。

结论

初级保健中控制 ASCVD 危险因素的差异仍然存在,并且不能完全用人口统计学或临床特征来解释。监测差异的变化对于确保公平性很重要,因为正在开发和实施旨在预防 ASCVD 的初级保健干预措施。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0baf/8457428/5937e11cb1e6/hpab053_iffig1.jpg

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